Evidence map›Paper›PMID 34122414›Full record

ArticleFrontiers in immunology2021

Systemic Characterization of Novel Immune Cell Phenotypes in Recurrent Pregnancy Loss.

Hong Liu, Xin-Xiu Lin, Xiao-Bo Huang, Dong-Hui Huang, Su Song, Yang-Jiao Chen, Jing Tang, Ding Tao, Zhi-Nan Yin, Gil Mor and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Mesenchymal stem cells for recurrent miscarriage.Journal of translational medicine · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Hong LiuInstitute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xin-Xiu LinInstitute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiao-Bo HuangInstitute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dong-Hui HuangInstitute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Su SongCenter for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yang-Jiao ChenCenter for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jing TangDepartment of Gynecology, Maternal and Child Health Hospital of Hubei Province, Wuhan, China.
Ding TaoSchool of Data Science, The Chinese University of Hong Kong, Shenzhen, China.
Zhi-Nan YinZhuhai Precision Medical Center, Zhuhai People's Hospital, Jinan University, Zhuhai, China.
Gil MorInstitute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ai-Hua LiaoInstitute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Huazhong University of Science and Technology · CNChinese University of Hong Kong, Shenzhen · CNJinan University · CNWayne State University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Recurrent pregnancy loss (RPL) is a disturbing disease in women, and 50% of RPL is reported to be associated with immune dysfunction. Most previous studies of RPL focused mainly on the relationship between RPL and either T cells or natural killer (NK) cells in peripheral blood and the decidua; few studies presented the systemic profiles of the peripheral immune cell subsets in RPL women. Herein, we simultaneously detected 63 immune cell phenotypes in the peripheral blood from nonpregnant women (NPW), women with a history of normal pregnancy (NP) and women with a history of RPL (RPL) by multi-parameter flow cytometry. The results demonstrated that the percentages of naïve CD4

Indexed as

Abortion, HabitualAdultBiomarkersDisease SusceptibilityFemaleFlow CytometryHumansImmunophenotypingKiller Cells, NaturalPregnancyReference ValuesT-Lymphocyte SubsetsYoung AdultBiomarkersflow cytometryimmune cellNK cellperipheral T helper cellrecurrent pregnancy lossγδT cell

Identifiers

PMID34122414
PMCPMC8195235
OpenAlexW3170550018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.