Evidence map›Paper›PMID 34122410›Full record

ArticleFrontiers in immunology2021

Immunosuppressive PLGA TGF-β1 Microparticles Induce Polyclonal and Antigen-Specific Regulatory T Cells for Local Immunomodulation of Allogeneic Islet Transplants.

Ying Li, Anthony W Frei, Irayme M Labrada, Yanan Rong, Jia-Pu Liang, Magdalena M Samojlik, Chuqiao Sun, Steven Barash, Benjamin G Keselowsky, Allison L Bayer and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Review
  3. Engineering the Immune Response to Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Unlocking Transplant Tolerance with Biomaterials.Advanced healthcare materials · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Biomaterial Strategies for Selective Immune Tolerance: Advances and Gaps.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ying LiJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
Anthony W FreiJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
Irayme M LabradaJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
Yanan RongJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
Jia-Pu LiangJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
Magdalena M SamojlikJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
Chuqiao SunJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
Steven BarashJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
Benjamin G KeselowskyJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
Allison L BayerDiabetes Research Institute, University of Miami, Miami, FL, United States.
Cherie L StablerJ. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States.
University of Florida · USUniversity of Miami · US

Funding

Engineering Ultrathin Immunomodulatory Coatings for Islet EncapsulationR01DK100654 · NIDDK · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI STABLER, CHERIE L · 2014 to 2018
$2.2M
Engineering Immunomodulatory Nanoscale Coatings for Protecting Islet TransplantsR01DK126413 · NIDDK · UNIVERSITY OF FLORIDA · PI STABLER, CHERIE L · 2020 to 2024
$1.7M
NIDDK NIH HHS R01 DK100654NIDDK NIH HHS R01 DK126413
6 · The paper itself

Abstract

Allogeneic islet transplantation is a promising cell-based therapy for Type 1 Diabetes (T1D). The long-term efficacy of this approach, however, is impaired by allorejection. Current clinical practice relies on long-term systemic immunosuppression, leading to severe adverse events. To avoid these detrimental effects, poly(lactic-co-glycolic acid) (PLGA) microparticles (MPs) were engineered for the localized and controlled release of immunomodulatory TGF-β1. The

Indexed as

AnimalsBlood GlucoseCoculture TechniquesDelayed-Action PreparationsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Drug CarriersDrug LiberationFeasibility StudiesGlucose Tolerance TestGraft RejectionHumansImmunologic FactorsImmunomodulationIslets of Langerhans TransplantationMaleBlood GlucoseDelayed-Action PreparationsDrug CarriersImmunologic FactorsPolylactic Acid-Polyglycolic Acid CopolymerRecombinant ProteinsStreptozocinTGFB1 protein, humanTransforming Growth Factor beta1biomaterialsextrahepatic islet transplantationimmunomodulatorylocal drug deliverytype 1 diabetes

Identifiers

PMID34122410
PMCPMC8190479
OpenAlexW3173081299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.