Evidence map›Paper›PMID 34122338›Full record

ArticleFrontiers in endocrinology2021

Decreased Expression of Ileal Thyroid Hormone Transporters in a Hypothyroid Patient: A Case Report.

Chae Won Chung, Eun Young Mo, Gyung Seo Jung, Yoo Hyung Kim, Sun Wook Cho, Do Joon Park, Jeong Mo Bae, Young Joo Park

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Optimal Thyroid Hormone Replacement.Endocrine reviews · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chae Won ChungDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Eun Young MoDepartment of Internal Medicine, The Catholic University of Korea Incheon St. Mary's Hospital, Incheon, South Korea.
Gyung Seo JungDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Yoo Hyung KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Sun Wook ChoDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Do Joon ParkDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Jeong Mo BaeDepartment of Pathology, Seoul National University Hospital, Seoul, South Korea.
Young Joo ParkDepartment of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Seoul National University Hospital · KRSeoul National University · KRThe Catholic University of Korea Incheon St. Mary's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Malabsorption of levothyroxine (LT4) is a common problem faced in clinical practice. It is usually solved, if there are no complexities including gastrointestinal absorption disorder, by taking medicines on an empty stomach and avoiding foods interfering with LT4. Herein we present a rare case of a patient exhibiting malabsorption of LT4 with decreased membranous expression of ileal transporters. Case: The 22-Year-old female presented with sustained hypothyroid status despite medication of 7.8 μg/kg LT4. Medical history and LT4 absorption test (the absorption rate 8.4%) excluded pseudomalabsorption. No organic gastrointestinal disorder was found in the patient by blood chemistry, endoscopies, and abdominal computed tomography scan. The immunohistochemical analysis showed decreased membranous expression of LAT1 and LAT2 in distal ileum and ascending colon in the patient compared to 20 controls who have no thyroid disease. The expression of MCT8 in colon appeared at both nucleus and brush border in the patient, while it was limited to brush border in controls. The expression of other transporters was similar between the patient and controls. Conclusion: The changes of the expression of LAT1 and LAT2 in this patient showing LT4 malabsorption might help to understand the role of intestinal transporters in the absorption of LT4 in humans. The functional relevance of the decrement of LAT1 and LAT2 in this patient remains to be elucidated.

Indexed as

Adaptor Proteins, Signal TransducingAdultCase-Control StudiesFemaleHumansHypothyroidismLarge Neutral Amino Acid-Transporter 1Malabsorption SyndromesPrognosisThyroxineTissue DistributionYoung AdultAdaptor Proteins, Signal TransducingLarge Neutral Amino Acid-Transporter 1LAT2 protein, humanSLC7A5 protein, humanThyroxinehypothyroidismimmunohistochemistrylevothyroxine absorption testmalabsorption of levothyroxinethyroid hormone transporter

Identifiers

PMID34122338
PMCPMC8187942
OpenAlexW3165302226

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.