Evidence map›Paper›PMID 34122333›Full record

ArticleFrontiers in endocrinology2021

Hyperthyroidism Prevalence in China After Universal Salt Iodization.

Chuyuan Wang, Yongze Li, Di Teng, Xiaoguang Shi, Jianming Ba, Bing Chen, Jianling Du, Lanjie He, Xiaoyang Lai, Yanbo Li and 26 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Efficacy and safety ofFrontiers in pharmacology · 2025
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  16. Climate changes affecting global iodine status.European thyroid journal · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors at 20 institutions in 1 country.

Chuyuan WangDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang, China.
Yongze LiDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang, China.
Di TengDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang, China.
Xiaoguang ShiDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang, China.
Jianming BaDepartment of Endocrinology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
Bing ChenDepartment of Endocrinology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Jianling DuDepartment of Endocrinology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Lanjie HeDepartment of Endocrinology, Cardiovascular and Cerebrovascular Disease Hospital, General Hospital of Ningxia Medical University, Jinfeng, China.
Xiaoyang LaiDepartment of Endocrinology and Metabolism, Second Affiliated Hospital of Nanchang University, Nanchang, China.
Yanbo LiDepartment of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Haiyi ChiDepartment of Endocrinology, Hohhot First Hospital, Hohhot, China.
Eryuan LiaoDepartment of Endocrinology and Metabolism, Second Xiangya Hospital, Central South University, Changsha, China.
Chao LiuResearch Center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Libin LiuFujian Institute of Hematology, Union Hospital, Fujian Medical University, Fuzhou, China.
Guijun QinInternational Medical Center, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Yingfen QinDepartment of Endocrinology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Huibiao QuanDepartment of Endocrinology, Hainan General Hospital, Haikou, China.
Bingyin ShiDepartment of Endocrinology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Hui SunDepartment of Endocrinology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xulei TangDepartment of Endocrinology, First Hospital of Lanzhou University, Lanzhou, China.
Nanwei TongState Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Guixia WangDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Jilin University, Changchun, China.
Jin-An ZhangDepartment of Endocrinology, Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Youmin WangDepartment of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yuanming XueDepartment of Endocrinology, The First People's Hospital of Yunnan Province, Kunming, China.
Li YanDepartment of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Jing YangDepartment of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, China.
Lihui YangDepartment of Endocrinology and Metabolism, People's Hospital of Tibet Autonomous Region, Lhasa, China.
Yongli YaoDepartment of Endocrinology, Qinghai Provincial People's Hospital, Xining, China.
Zhen YeZhejiang Center for Disease Control and Prevention (Zhejiang CDC), Hangzhou, China.
Qiao ZhangDepartment of Endocrinology and Metabolism, Affiliated Hospital of Guiyang Medical University, Guiyang, China.
Lihui ZhangDepartment of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China.
Jun ZhuDepartment of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Mei ZhuDepartment of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.
Zhongyan ShanDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang, China.
Weiping TengDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang, China.
First Hospital of China Medical University · CNChina Medical University · CNAnhui Medical University · CNCentral South University · CNChinese People's Liberation Army · CNDalian Medical University · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNFirst Affiliated Hospital of Xinjiang Medical University · CNFirst Affiliated Hospital of Zhengzhou University · CNFirst Hospital of Lanzhou University · CNFirst Hospital of Shanxi Medical University · CNFirst People's Hospital of Yunnan Province · CNFujian Medical University · CNGuangxi Medical University · CNGuiyang Medical University · CNHainan General Hospital · CNHebei Medical University · CNHohhot First Hospital · CNJilin University · CNNanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Universal salt iodization (USI) was implemented in mainland China in 1996. The prevalence of hyperthyroidism and its risk factors now require examination. Methods: Data were acquired from a nationwide Thyroid, Iodine, and Diabetes Epidemiological survey (TIDE 2015-2017) of 78,470 subjects from 31 provinces. Iodine status, and thyroid hormones and antibodies were measured. Results: After two decades of USI, the prevalence of overt hyperthyroidism (OH), Graves' disease (GD), severe subclinical hyperthyroidism (severe SCH), and mild subclinical hyperthyroidism (mild SCH) in mainland China was 0.78%, 0.53%, 0.22%, and 0.22%, respectively. OH and GD prevalence were higher in women than in men (OH: 1.16% Conclusion: OH and GD prevalences in mainland China are stable after two decades of USI. Iodine deficiency, elevated thyroid antibody levels, and middle age are the main risk factors for OH and GD. The severe SCH population, rather than the mild SCH population, shows similar characteristics to the OH population.

Indexed as

Sodium Chloride, DietaryAdultAntibodiesChinaElectrochemistryFemaleGraves DiseaseHumansHyperthyroidismIodineLuminescenceMaleMiddle AgedPrevalenceRiskRisk FactorsAntibodiesIodineiodized saltSodium Chloride, Dietarycross-sectional studyGraves’ diseasehyperthyroidismiodine intakethyroid autoimmune antibodies

Identifiers

PMID34122333
PMCPMC8194401
OpenAlexW3169145369

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.