ArticleFrontiers in neurology2021
Different Functional Network Connectivity Patterns in Epilepsy: A Rest-State fMRI Study on Mesial Temporal Lobe Epilepsy and Benign Epilepsy With Centrotemporal Spike.
Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 16 citations in OpenAlex.
- Resting-State fMRI Functional Connectivity Alterations in Drug-Resistant Epilepsy Compared to Well-Controlled Epilepsy and Healthy Controls.Neurology international · 2026Article
- Childhood absence epilepsy and distinct dynamic functional network connectivity patterns in self-limited epilepsy with centrotemporal spikes: a resting-state fMRI study.Pediatric research · 2026Article
- sEEG-guided responsive neurostimulation to treat neocortical epilepsy: A multicenter retrospective study of the efficacy and safety of depth electrode-mediated neuromodulation.Epilepsia open · 2026Article
- Mapping global brain reconfigurations following local targeted manipulations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- MRI based early Temporal Lobe Epilepsy detection using DGWO based optimized HAETN and Fuzzy-AAL Segmentation Framework (FASF).PloS one · 2025Article
- The changes in brain network functional gradients and dynamic functional connectivity in SeLECTS patients revealing disruptive and compensatory mechanisms in brain networks.Frontiers in psychiatry · 2025Article
- Inhibiting Inducible Nitric Oxide Synthase with 1400W Reduces Soman (GD)-Induced Ferroptosis in Long-Term Epilepsy-Associated Neuropathology: Structural and Functional Magnetic Resonance Imaging Correlations with Neurobehavior and Brain Pathology.The Journal of pharmacology and experimental therapeutics · 2024Article
- Delineating abnormal individual structural covariance brain network organization in pediatric epilepsy with unilateral resection of visual cortex.Epilepsy & behavior reports · 2024Article
- Altered Language-Related Effective Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes.Life (Basel, Switzerland) · 2023Article
- Amplitude synchronization of spontaneous activity of medial and lateral temporal gyri reveals altered thalamic connectivity in patients with temporal lobe epilepsy.Scientific reports · 2022Article
- Networks of cortical activity in infants with epilepsy.Brain communications · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The stark discrepancy in the prognosis of epilepsy is closely related to brain damage features and underlying mechanisms, which have not yet been unraveled. In this study, differences in the epileptic brain functional connectivity states were explored through a network-based connectivity analysis between intractable mesial temporal lobe epilepsy (MTLE) patients and benign epilepsy with centrotemporal spikes (BECT). Resting state fMRI imaging data were collected for 14 MTLE patients, 12 BECT patients and 16 healthy controls (HCs). Independent component analysis (ICA) was performed to identify the cortical functional networks. Subcortical nuclei of interest were extracted from the Harvard-Oxford probability atlas. Network-based statistics were used to detect functional connectivity (FC) alterations across intranetworks and internetworks, including the connectivity between cortical networks and subcortical nuclei. Compared with HCs, MTLE patients showed significant lower activity between the connectivity of cortical networks and subcortical nuclei (especially hippocampus) and lower internetwork FC involving the lateral temporal lobe; BECT patients showed normal cortical-subcortical FC with hyperconnectivity between cortical networks. Together, cortical-subcortical hypoconnectivity in MTLE suggested a low efficiency and collaborative network pattern, and this might be relevant to the final decompensatory state and the intractable prognosis. Conversely, cortical-subcortical region with normal connectivity remained well in global cooperativity, and compensatory internetwork hyperconnectivity caused by widespread cortical abnormal discharge, which might account for the self-limited clinical outcome in BECT. Based on the fMRI functional network study, different brain network patterns might provide a better explanation of mechanisms in different types of epilepsy.
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