ArticleFrontiers in psychiatry2021
Reward Processing and Circuit Dysregulation in Posttraumatic Stress Disorder.
Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Impaired learning, memory, and extinction in posttraumatic stress disorder: translational meta-analysis of clinical and preclinical studies.Translational psychiatry · 2023Pooled it
- Neural Correlates of Maternal Posttraumatic Stress in the First Postpartum Year: Blunted Salience and Prefrontal Responses to Infant Distress.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Increases in striatal response to reward anticipation relate to reductions in impulsivity in women with substance use disorders.NeuroImage. Clinical · 2026Article
- Anhedonia underlies the association between childhood unpredictability and adult PTSD symptoms: Evidence from three independent longitudinal cohorts.Psychological medicine · 2026Article
- Posttraumatic stress, anxiety, and depression in mothers after preterm delivery and the associated psychological processes.BMC pregnancy and childbirth · 2025Article
- Ibogaine's potential role in supporting reward system recovery across diagnostic boundaries.Frontiers in pharmacology · 2025Article
- The gut and heart's role in reward processing.Frontiers in integrative neuroscience · 2025Review
- Neuronal Mechanisms of Reading Informational Texts in People with Different Levels of Mental Resilience.Brain sciences · 2024Article
- Neurobiology and systems biology of stress resilience.Physiological reviews · 2024Review
- Prefrontal control of superior colliculus modulates innate escape behavior following adversity.Nature communications · 2024Article
- The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology.Stress (Amsterdam, Netherlands) · 2024Review
- Ketamine for Treatment of Posttraumatic Stress Disorder: State of the Field.Focus (American Psychiatric Publishing) · 2023Review
- Biological Psychiatry in Displaced Populations: What We Know, and What We Need to Begin to Learn.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Review
- Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits.Nature reviews. Neurology · 2022Review
- Repurposing Existing Drugs for the Treatment of Post-Traumatic Stress Disorder.Chronic stress (Thousand Oaks, Calif.)Review
- Brick by Brick: Building a Transdiagnostic Understanding of Inflammation in Psychiatry.Harvard review of psychiatryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Past decades have witnessed substantial progress in understanding of neurobiological mechanisms that contribute to generation of various PTSD symptoms, including intrusive memories, physiological arousal and avoidance of trauma reminders. However, the neurobiology of anhedonia and emotional numbing in PTSD, that have been conceptualized as reward processing deficits - reward wanting (anticipation of reward) and reward liking (satisfaction with reward outcome), respectively, remains largely unexplored. Empirical evidence on reward processing in PTSD is rather limited, and no studies have examined association of reward processing abnormalities and neurocircuitry-based models of PTSD pathophysiology. The manuscript briefly summarizes "state of the science" of both human reward processing, and of PTSD implicated neurocircuitry, as well as empirical evidence of reward processing deficits in PTSD. We then summarize current gaps in the literature and outline key future directions, further illustrating it by the example of two alternative explanations of PTSD pathophysiology potentially affecting reward processing via different neurobiological pathways. Studying reward processing in PTSD will not only advance the understanding of their link, but also could enhance current treatment approaches by specifically targeting anhedonia and emotional symptoms in PTSD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.