Evidence map›Paper›PMID 34122146›Full record

ArticleFrontiers in physiology2021

Comparison of Cortical Autonomic Network-Linked Sympathetic Excitation by Mueller Maneuvers and Breath-Holds in Subjects With and Without Obstructive Sleep Apnea.

Keri S Taylor, Daniel A Keir, Nobuhiko Haruki, Derek S Kimmerly, Philip J Millar, Hisayoshi Murai, John S Floras

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Sympathetic neural responses to sleep disorders and insufficiencies.American journal of physiology. Heart and circulatory physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Keri S TaylorUniversity Health Network and Mount Sinai Hospital Department of Medicine, Toronto General Hospital Research Institute and the Department of Medicine, University of Toronto, Toronto, ON, Canada.
Daniel A KeirUniversity Health Network and Mount Sinai Hospital Department of Medicine, Toronto General Hospital Research Institute and the Department of Medicine, University of Toronto, Toronto, ON, Canada.
Nobuhiko HarukiUniversity Health Network and Mount Sinai Hospital Department of Medicine, Toronto General Hospital Research Institute and the Department of Medicine, University of Toronto, Toronto, ON, Canada.
Derek S KimmerlyUniversity Health Network and Mount Sinai Hospital Department of Medicine, Toronto General Hospital Research Institute and the Department of Medicine, University of Toronto, Toronto, ON, Canada.
Philip J MillarUniversity Health Network and Mount Sinai Hospital Department of Medicine, Toronto General Hospital Research Institute and the Department of Medicine, University of Toronto, Toronto, ON, Canada.
Hisayoshi MuraiUniversity Health Network and Mount Sinai Hospital Department of Medicine, Toronto General Hospital Research Institute and the Department of Medicine, University of Toronto, Toronto, ON, Canada.
John S FlorasUniversity Health Network and Mount Sinai Hospital Department of Medicine, Toronto General Hospital Research Institute and the Department of Medicine, University of Toronto, Toronto, ON, Canada.
University Health Network · CAMount Sinai Hospital · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In healthy young volunteers, acquisition of blood oxygen level-dependent (BOLD) magnetic resonance (MR) and muscle sympathetic nerve (MSNA) signals during simulation of obstructive or central sleep apnea identified cortical cardiovascular autonomic regions in which the BOLD signal changed synchronously with acute noradrenergic excitation. In the present work, we tested the hypothesis that such Mueller maneuvers (MM) and breath-holds (BH) would elicit greater concomitant changes in mean efferent nerve firing and BOLD signal intensity in patients with moderate to severe obstructive sleep apnea (OSA) relative to age- and sex-matched individuals with no or only mild OSA (Apnea Hypopnea Index, AHI, <15 events/h). Forty-six participants, 24 with OSA [59 ± 8 years; AHI 31 ± 18 events/h (mean ± SD); seven women] and 22 without (58 ± 11 years; AHI 7 ± 4; nine women), performed a series of three MM and three BH, in randomly assigned order, twice: during continuous recording of MSNA from the right fibular nerve and, on a separate day, during T2

Indexed as

breath holdfunctional magnetic resonance imaging (fMRI)Mueller maneuversleep apneasympathetic nerve activity

Identifiers

PMID34122146
PMCPMC8188800
OpenAlexW3165850135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.