Evidence map›Paper›PMID 34122128›Full record

ArticleFrontiers in physiology2021

Immediate and Delayed Response of Simulated Human Atrial Myocytes to Clinically-Relevant Hypokalemia.

Michael Clerx, Gary R Mirams, Albert J Rogers, Sanjiv M Narayan, Wayne R Giles

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Leak current, even with gigaohm seals, can cause misinterpretation of stem cell-derived cardiomyocyte action potential recordings.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Michael ClerxCentre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom.
Gary R MiramsCentre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom.
Albert J RogersDepartment of Medicine and Cardiovascular Institute, Stanford University, Stanford, CA, United States.
Sanjiv M NarayanDepartment of Medicine and Cardiovascular Institute, Stanford University, Stanford, CA, United States.
Wayne R GilesDepartment of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada.
University of Nottingham · GBCardiovascular Institute of the South · USStanford University · USUniversity of Calgary · CA

Funding

The Dynamics of Human Atrial FibrillationR01HL083359 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sanjiv M Narayan · 2008 to 2026
$7.9M
Machine Learning in Atrial FibrillationR01HL149134 · NHLBI · STANFORD UNIVERSITY · PI NARAYAN, SANJIV M · 2020 to 2024
$3.8M
NHLBI NIH HHS R01 HL083359NHLBI NIH HHS R01 HL149134Wellcome Trust 212203/Z/18/Z
6 · The paper itself

Abstract

Although plasma electrolyte levels are quickly and precisely regulated in the mammalian cardiovascular system, even small transient changes in K

Indexed as

action potential repolarizationatrial fibrillation (AF)hypokalemiainwardly rectifying K+ currentmathematical modelingplasma potassium levelsrenal dialysissodium potassium (Na+/K+-ATPase) pump

Identifiers

PMID34122128
PMCPMC8188899
OpenAlexW3164623611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.