Evidence map›Paper›PMID 34122116›Full record

ArticleFrontiers in pharmacology2021

Asiatic Acid Induces Endoplasmic Reticulum Stress and Activates the Grp78/IRE1α/JNK and Calpain Pathways to Inhibit Tongue Cancer Growth.

Jialin Li, Kan Chen, Jianhua Huang, Dongqing Chu, Miaomiao Tian, Keqiang Huang, Chunyu Ma

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Can Asiatic Acid fromCancers · 2024
    Review
  4. Review
  5. Article
  6. Journal of oral and maxillofacial pathology : JOMFP
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jialin LiFirst Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Kan ChenFirst Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Jianhua HuangFirst Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Dongqing ChuGraduated School of Jinzhou Medical University, Jinzhou, China.
Miaomiao TianFirst Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Keqiang HuangSecond Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Chunyu MaFirst Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Jinzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asiatic acid (AA) has been shown to induce apoptotic death in a range of cancers, but the mechanisms whereby it can inhibit tongue cancer growth have yet to be clarified. Herein, we explored the effects of AA on tongue cancer cells and found that it induced their apoptotic death

Indexed as

apoptosisasiatic acidcalpainendoplasmic reticulum stressGRP78tongue cancer

Identifiers

PMID34122116
PMCPMC8187906
OpenAlexW3165368567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.