ArticleFrontiers in pharmacology2021
New Viscoelastic Hydrogel Hymovis MO.RE. Single Intra-articular Injection for the Treatment of Knee Osteoarthritis in Sportsmen: Safety and Efficacy Study Results.
Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- The Effects of Hyaluronic Acid on Gait Parameters in Patients with Knee Osteoarthritis: A Systematic Literature Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Association of muscle wasting with mortality risk among adults: A systematic review and meta-analysis of prospective studies.Journal of cachexia, sarcopenia and muscle · 2023Pooled it
- Efficacy and safety of radiofrequency treatment for improving knee pain and function in knee osteoarthritis: a meta-analysis of randomized controlled trials.Journal of orthopaedic surgery and research · 2022Pooled it
- A comparative analysis of prolotherapy efficacy in patients with knee osteoarthritis across varied dextrose concentrations.Clinical rheumatology · 2023Trial
- A pilot randomized controlled trial evaluating outdoor community walking for knee osteoarthritis: walk.Clinical rheumatology · 2023Trial
- The quality of physiotherapy and rehabilitation program and the effect of telerehabilitation on patients with knee osteoarthritis.Clinical rheumatology · 2023Trial
- Hemp Seed Oil in Association with β-Caryophyllene, Myrcene and Ginger Extract as a Nutraceutical Integration in Knee Osteoarthritis: A Double-Blind Prospective Case-Control Study.Medicina (Kaunas, Lithuania) · 2023Trial
- Temporal Hierarchy of Hydrogels and Orthobiologic Therapies for Knee Osteoarthritis.Gels (Basel, Switzerland) · 2026Review
- Single-injection hyaluronic acid treatment demonstrates non-inferiority in the relief of symptomatic knee osteoarthritis: A randomized double-blind, multi-center controlled study.Osteoarthritis and cartilage open · 2026Article
- Effect of tele-rehabilitation on health outcomes in overweight and obese elderly women with locomotor disabilities from knee osteoarthritis: A randomised controlled trial.Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liao · 2026Article
- Article
- Rheological properties and clinical efficacy of a chemically modified hyaluronic acid for joint health enhancement.Drugs in context · 2026Review
- Injectable Porcine Collagen in Musculoskeletal Disorders: A Delphi Consensus.Journal of clinical medicine · 2025Article
- Molecular Mechanisms and Therapeutic Role of Intra-Articular Hyaluronic Acid in Osteoarthritis: A Precision Medicine Perspective.Journal of clinical medicine · 2025Review
- Intra-Articular Hyaluronic Acid for Knee Osteoarthritis: A Systematic Umbrella Review.Journal of clinical medicine · 2025Review
- Musculoskeletal Diseases: Aetiology, Clinical Implications, Rehabilitation and Treatment.Journal of personalized medicine · 2025Article
- Research progress on biodegradable polymer-based drug delivery systems for the treatment of knee osteoarthritis.Frontiers in bioengineering and biotechnology · 2025Review
- The Effect of Intra-Articular Injections of Hyaluronic Acid for the Treatment of Trapezio-Metacarpal Joint Osteoarthritis.Journal of personalized medicine · 2024Article
- Article
- A Cross-Sectional Study of Factors Predicting the Duration of the Efficacy of Viscosupplementation in Knee Osteoarthritis.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viscosupplementation by hyaluronic acid (HA) is recommended for non-surgical management of knee osteoarthritis (OA). This study investigated the efficacy and safety of a single i.a. (32 mg/4 ml) Hymovis MO.RE. injection, a new HA derivative hydrogel, for the treatment of adult regular sports players affected by knee OA arising from overuse injuries. Patients were prospectively enrolled if regularly practicing sports and diagnosed with Kellgren-Lawrence grade I-III OA. They received a single Hymovis MO.RE. intra-articular (i.a.) injection and were evaluated 30, 90, 180, and 360 days thereafter. The assessment involved measuring changes in knee function, pain, the activity of daily living (ADL), and quality of life (QOL) by using the Knee injury and Osteoarthritis Outcome Score (KOOS), GAIT analysis, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores for knee pain (WOMAC A) and function (WOMAC C), and a visual analogue scale (VAS) pain score. The study involved thirty-one patients, 23 women and eight men, whose median age was 49. KOOS function subscore, as well as GAIT cadence and velocity, showed a statistically significant increase at each time-point after injection (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.