Evidence map›Paper›PMID 34122097›Full record

ArticleFrontiers in pharmacology2021

HLA Risk Alleles in Aromatic Antiepileptic Drug-Induced Maculopapular Exanthema.

Yi-Wu Shi, Jie Wang, Fu-Li Min, Wen-Jun Bian, Bi-Jun Mao, Yong Mao, Bing Qin, Bing-Mei Li, Yang-Mei Ou, Yun-Qi Hou and 15 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 13 institutions in 2 countries.

Yi-Wu ShiInstitute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China.
Jie WangInstitute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China.
Fu-Li MinDepartment of Neurology, Guangzhou First People's Hospital, Guangzhou, China.
Wen-Jun BianInstitute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China.
Bi-Jun MaoInstitute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China.
Yong MaoBGI-Shenzhen, Shenzhen, China.
Bing QinEpilepsy Center and Department of Neurosurgery, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Bing-Mei LiInstitute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China.
Yang-Mei OuDepartment of Neurology, Guangdong 999 Brain Hospital, Guangzhou, China.
Yun-Qi HouThe First People's Hospital of Shunde, Foshan, China.
Xin ZouThe Third People's Hospital of Mianyang, Mianyang, China.
Bao-Zhu GuanInstitute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China.
Na HeInstitute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China.
Yong-Jun ChenDepartment of Neurology, Nanhua Hospital Affiliated to South China University, Hengyang, China.
Xue-Lian LiDepartment of Neurology, The Affiliated Yuebei People's Hospital of Shantou University Medical College, Shaoguan, China.
Juan WangThe Affiliated Hospital of Xiangnan University, Chenzhou, China.
Wei-Yi DengInstitute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China.
Han-Kui LiuBGI-Shenzhen, Shenzhen, China.
Nan-Xiang ShenInstitute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China.
Xiao-Rong LiuInstitute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China.
Yong-Hong YiInstitute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China.
Lie-Min ZhouDepartment of Neurology, The Seventh Affiliated Hospital, Sun Yat-Set University, Guangzhou, China.
Dong ZhouWest China Hospital, Sichuan University, Chengdu, China.
Patrick KwanDepartment of Neuroscience, Central Clinical School, Monash University, Alfred Hospital, Melbourne, VIC, Australia.
Wei-Ping LiaoInstitute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University; Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou, China.
Ministry of Education of the People's Republic of China · CNGuangzhou Medical University · CNSecond Affiliated Hospital of Guangzhou Medical University · CNBGI Group (China) · CNFirst Affiliated Hospital of Jinan University · CNGuangdong 999 Brain Hospital · CNMianyang Third People's Hospital · CNMonash University · AUSichuan University · CNThe First People's Hospital of Shunde · CNThe Seventh Affiliated Hospital of Sun Yat-sen University · CNUniversity of South China · CNYue Bei People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To characterize human leukocyte antigen (HLA) loci as risk factors in aromatic antiepileptic drug-induced maculopapular exanthema (AED-MPE). A case-control study was performed to investigate HLA loci involved in AED-MPE in a southern Han Chinese population. Between January 2007 and June 2019, 267 patients with carbamazepine (CBZ), oxcarbazepine (OXC), or lamotrigine (LTG) associated MPE and 387 matched drug-tolerant controls from six centers were enrolled. HLA-A/B/C/DRB1 genotypes were determined using sequence-based typing. Potential risk alleles were validated by meta-analysis using data from different populations and

Indexed as

antiepileptic drugshuman leukocyte antigenmaculopapular exanthemaoxcarbazepinerisk factor

Identifiers

PMID34122097
PMCPMC8187898
OpenAlexW3164906780

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.