Evidence map›Paper›PMID 34122051›Full record

ArticleFrontiers in aging neuroscience2021

Similar Genetic Architecture of Alzheimer's Disease and Differential

Hao Wang, Min-Tzu Lo, Sara Brin Rosenthal, Carolina Makowski, Ole A Andreassen, Rany M Salem, Linda K McEvoy, Mark Fiecas, Chi-Hua Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Genetic characterization of the ALFA study: Uncovering genetic profiles in the Alzheimer's continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  10. Among men, androgens are associated with a decrease in Alzheimer's disease risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Hao WangDepartment of Radiology, Center for Multimodal Imaging and Genetics, University of California, San Diego, San Diego, CA, United States.
Min-Tzu LoDepartment of Radiology, Center for Multimodal Imaging and Genetics, University of California, San Diego, San Diego, CA, United States.
Sara Brin RosenthalCenter for Computational Biology and Bioinformatics, University of California, San Diego, San Diego, CA, United States.
Carolina MakowskiDepartment of Radiology, Center for Multimodal Imaging and Genetics, University of California, San Diego, San Diego, CA, United States.
Ole A AndreassenDivision of Mental Health and Addiction, NORMENT Centre, University of Oslo and Oslo University Hospital, Oslo, Norway.
Rany M SalemDepartment of Family Medicine and Public Health, Division of Epidemiology, University of California, San Diego, San Diego, CA, United States.
Linda K McEvoyDepartment of Radiology, Center for Multimodal Imaging and Genetics, University of California, San Diego, San Diego, CA, United States.
Mark FiecasSchool of Public Health, Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States.
Chi-Hua ChenDepartment of Radiology, Center for Multimodal Imaging and Genetics, University of California, San Diego, San Diego, CA, United States.
University of California, San Diego · USUniversity of Minnesota · USUniversity of Oslo · NO

Funding

Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
Genetic architecture of the human brain and neuropsychiatric disordersR01MH118281 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, CHI-HUA · 2019 to 2023
$2.7M
Omic analyses for stratifying Alzheimer's subtypes and identifying novel drug targetsR56AG061163 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, CHI-HUA · 2018 to 2018
$560k
NIA NIH HHS R56 AG061163NIA NIH HHS U01 AG032984NIMH NIH HHS R01 MH118281
6 · The paper itself

Abstract

Sex differences have been observed in the clinical manifestations of Alzheimer's disease (AD) and elucidating their genetic basis is an active research topic. Based on autosomal genotype data of 7,216 men and 10,680 women, including 8,136 AD cases and 9,760 controls, we explored sex-related genetic heterogeneity in AD by investigating SNP heritability, genetic correlation, as well as SNP- and gene-based genome-wide analyses. We found similar SNP heritability (men: 19.5%; women: 21.5%) and high genetic correlation (

Indexed as

Alzheimer’s diseasegenetic heterogeneitygenome-wide association studyheritabilitysex difference

Identifiers

PMID34122051
PMCPMC8194397
OpenAlexW3172789506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.