Evidence map›Paper›PMID 34122046›Full record

ArticleFrontiers in aging neuroscience2021

Better Identification of Cognitive Decline With Interleukin-2 Than With Amyloid and Tau Protein Biomarkers in Amnestic Mild Cognitive Impairment.

Chih-Sung Liang, Chia-Lin Tsai, Guan-Yu Lin, Jiunn-Tay Lee, Yu-Kai Lin, Che-Sheng Chu, Yueh-Feng Sung, Chia-Kuang Tsai, Ta-Chuan Yeh, Hsuan-Te Chu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Circulating Biomarkers for the Early Diagnosis of Alzheimer's Disease.International journal of molecular sciences · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. VEGF controls microglial phagocytic response to amyloid-β.Frontiers in cellular neuroscience · 2023
    Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Chih-Sung LiangDepartment of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chia-Lin TsaiDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Guan-Yu LinDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Jiunn-Tay LeeDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Yu-Kai LinGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
Che-Sheng ChuDepartment of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Yueh-Feng SungDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chia-Kuang TsaiDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Ta-Chuan YehDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Hsuan-Te ChuDepartment of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Ming-Wei SuInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Fu-Chi YangGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
Tri-Service General Hospital · TWNational Defense Medical Center · TWInstitute of Biomedical Sciences, Academia Sinica · TWKaohsiung Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rate of cognitive decline among patients with amnestic mild cognitive impairment (aMCI) varies, and it is thus crucial to accurately predict the probability of cognitive deterioration in patients with MCI. We compared the potential of cytokines with amyloid beta (Aβ) and tau biomarkers for predicting cognitive decline in patients with aMCI or Alzheimer's disease (AD). All participants (controls, aMCI, and AD patients) underwent plasma biomarker examinations for Aβ

Indexed as

Alzheimer’s diseaseamnestic mild cognitive impairmentbeta amyloidinterleukin-2predictive biomarkerstau protein

Identifiers

PMID34122046
PMCPMC8193360
OpenAlexW3167840999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.