Evidence map›Paper›PMID 34121984›Full record

ArticleFrontiers in neuroscience2021

Metabolomic Characterization of Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS).

Federica Murgia, Antonella Gagliano, Marcello G Tanca, Noga Or-Geva, Aran Hendren, Sara Carucci, Manuela Pintor, Francesca Cera, Fausto Cossu, Stefano Sotgiu and 2 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07718958 (BIOMA-PANS - Diagnostic and Treatment-response BIOMArkers in Children and Adolescents With PANS), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07718958 recruitingnot on this mapstarted 2024, after this paper: background citation

BIOMA-PANS - Diagnostic and Treatment-response BIOMArkers in Children and Adolescents With PANS (Pediatric Acute-onset Neuropsychiatric Syndrome)

Typeobservational_patient_registrySponsorUniversity of CagliariRan2024 to 2027Enrolled80ConditionsPANS, Pediatric Acute-Onset Neuropsychiatric SyndromeArmsPsycodiagnostic evaluation, Polysomnography, 1H-NMR analysis, miRNA sequencing
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Molecular Landscape of Tourette's Disorder.International journal of molecular sciences · 2023
    Article
  5. Review
  6. Journal of clinical medicine · 2022
    Article
  7. Article
  8. Neuroinflammation in a Rat Model of Tourette Syndrome.Frontiers in behavioral neuroscience · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Federica MurgiaClinical Metabolomics Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Antonella GaglianoChild and Adolescent Neuropsychiatry Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Marcello G TancaChild and Adolescent Neuropsychiatry Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Noga Or-GevaInterdepartmental Program in Immunology, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, United States.
Aran HendrenClinical Metabolomics Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Sara CarucciChild and Adolescent Neuropsychiatry Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Manuela PintorChild and Adolescent Neuropsychiatry Unit, "A. Cao" Peditric Hosptal, "G. Brotzu" Hospital Trust, Cagliari, Italy.
Francesca CeraChild and Adolescent Neuropsychiatry Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Fausto CossuPaediatric Clinic, "A. Cao" Hospital, Cagliari, Italy.
Stefano SotgiuChild Neuropsychiatry Unit, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Luigi AtzoriClinical Metabolomics Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Alessandro ZuddasChild and Adolescent Neuropsychiatry Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
University of Cagliari · ITAzienda Ospedaliera G. Brotzu · ITStanford University · USUniversity of Sassari · ITUniversity of Surrey · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPANS is a controversial clinical entity, consisting of a complex constellation of psychiatric symptoms, adventitious changes, and expression of various serological alterations, likely sustained by an autoimmune/inflammatory disease. Detection of novel biomarkers of PANS is highly desirable for both diagnostic and therapeutic management of affected patients. Analysis of metabolites has proven useful in detecting biomarkers for other neuroimmune-psychiatric diseases. Here, we utilize the metabolomics approach to determine whether it is possible to define a specific metabolic pattern in patients affected by PANS compared to healthy subjects.

designThis observational case-control study tested consecutive patients referred for PANS between June 2019 to May 2020. A PANS diagnosis was confirmed according to the PANS working criteria (National Institute of Mental Health [NIMH], 2010). Healthy age and sex-matched subjects were recruited as controls.

methodsThirty-four outpatients referred for PANS (mean age 9.5 years; SD 2.9, 71% male) and 25 neurotypical subjects matched for age and gender, were subjected to metabolite analysis. Serum samples were obtained from each participant and were analyzed using Nuclear Magnetic Resonance (NMR) spectroscopy. Subsequently, multivariate and univariate statistical analyses and Receiver Operator Curves (ROC) were performed.

resultsSeparation of the samples, in line with the presence of PANS diagnosis, was observed by applying a supervised model (R

conclusionWe found a unique plasma metabolic profile in PANS patients, significantly differing from that of healthy children, that suggests the involvement of specific patterns of neurotransmission (tryptophan, glycine, histamine/histidine) as well as a more general state of neuroinflammation and oxidative stress (glutamine, 2-Hydroxybutyrate, and tryptophan-kynurenine pathway) in the disorder. This metabolomics study offers new insights into biological mechanisms underpinning the disorder and supports research of other potential biomarkers implicated in PANS.

Indexed as

biomarkersmetabolomicsneuroinflammationoxidative stresspediatric acute-onset neuropsychiatric syndrome

Identifiers

PMID34121984
PMCPMC8194687
OpenAlexW3168555659

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.