ArticleDose-response : a publication of International Hormesis Society
Investigating Dual-Energy CT Post-Contrast Phases for Liver Iron Quantification: A Preliminary Study.
Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Photon-Counting Computed Tomography-Based Hepatic iron Quantification Using a Tungsten-Based Contrast Agent.Investigative radiology · 2025Article
- Fat quantification in dual-layer detector spectral CT: How to handle iron overload, varying tube voltage and radiation dose Indices.PloS one · 2024Article
- Regional Analysis of Liver Surface Nodularity in a Single Axial MR Image for Staging Liver Fibrosis.Journal of magnetic resonance imaging : JMRI · 2022Article
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6 authors at 1 institution in 1 country.
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Abstract
background and purposeQuantification of hepatic virtual iron content (VIC) by using Multidetector Dual Energy Computed Tomography (DECT) has been recently investigated since this technique could offer a good compromise between accuracy and non-invasiveness for liver iron content quantification. The aim of our study is to investigate differences in VIC at different DECT time points (namely baseline and arterial, venous and tardive phases), identifying the most reliable and also exploring the underlying temporal trend of these values. MATERIALS AND
methodsEleven patients who underwent DECT examination and were characterized by low liver fat content were included in this retrospective study. By using the Syngo.via Frontier-DE IronVNC tool, regions of interest (ROI) were placed on the VIC images at 3 hepatic levels, both in left and right liver lobes, at each DECT time point. Friedman's test followed by Bonferroni-adjusted Wilcoxon signed-rank test for post-hoc analysis was performed to assess differences between DECT timepoints. Page's L test was performed to test the temporal trend of VIC across the 4 examined timepoints.
resultsFor both liver lobes, Friedman's test followed by Bonferroni-adjusted Wilcoxon signed-rank test revealed that VIC values differed significantly when extracted from ROIs placed at the 4 different timepoints. The Page's L test for multiple comparison revealed a significant growing trend for VIC, from baseline acquisition to the fourth and last time point post-contrast agent injection.
conclusionsThe extraction of hepatic VIC in healthy subjects was found to be significantly influenced by the DECT time point chosen for the extrapolation of the VIC values.
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