Evidence map›Paper›PMID 34121829›Full record

ArticleProgress in pediatric cardiology2021

COVID-19 associated Multisystem Inflammatory Syndrome in Children (MIS-C) guidelines; revisiting the Western New York approach as the pandemic evolves.

Teresa R Hennon, Karl O A Yu, Michelle D Penque, Rabheh Abdul-Aziz, Arthur C Chang, Megan B McGreevy, John V Pastore, Andrew J Prout, Beverly A Schaefer, Omar S Alibrahim and 2 more

Open access · greenAbstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Progress in pediatric cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. MIS-C: Diagnosis, Management, and Outcomes.Open forum infectious diseases · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Teresa R HennonDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States of America.
Karl O A YuDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States of America.
Michelle D PenqueDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States of America.
Rabheh Abdul-AzizDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States of America.
Arthur C ChangDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States of America.
Megan B McGreevyDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States of America.
John V PastoreDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States of America.
Andrew J ProutWayne State University School of Medicine, Detroit, MI, United States of America.
Beverly A SchaeferDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States of America.
Omar S AlibrahimDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States of America.
Oscar G Gomez-DuarteDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States of America.
Mark D HicarDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, United States of America.
Women & Children's Hospital of Buffalo · USUniversity at Buffalo, State University of New York · USChildren's Hospital of Michigan · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multisystem inflammatory syndrome of children (MIS-C) continues to be a highly concerning diagnosis in those recently infected with SARS-CoV-2. The diagnosis of MIS-C cases will likely become even more challenging as vaccine uptake and natural immunity in previously infected persons leads to lower circulating rates of SARS-CoV-2 infection and will make cases sporadic. Febrile children presenting with cardiac dysfunction, symptoms overlapping Kawasaki disease or significant gastrointestinal complaints warrant a thorough screen in emergency departments, urgent care centers, and outpatient pediatric or family medicine practices. An increased index of suspicion and discussion regarding higher level of care (transferring to pediatric tertiary care centers or to intensive care) continues to be recommended. Herein we outline a broad approach with a multidisciplinary team for those meeting the case definition and believe such an approach is crucial for successful outcomes.

Indexed as

AP, approvedASO, anti-streptolysin OBNP, brain-natriuretic peptideCDC, Center for Disease ControlCOVID-19COVID-19, coronavirus disease 2019CRP, C-reactive proteinCXCL10, C-X-C-motif chemokine ligand 10DCBLD2, Discoidin, CUB and LCCL domain-containing protein 2ECMO, extracorporeal membrane oxygenationE, envelope proteinEKG, electrocardiogramEM, emergency useE.U., European UnionFDA, US Food and Drug AuthorityFeverGI, gastrointestinalIL, interleukinInflammationIVIG, intravenous immunoglobulin GKD, Kawasaki diseaseLDH, lactate dehydrogenaseLFTs, liver function testsMIS-CMIS-C, Multisystem Inflammatory Syndrome in ChildrenM, membrane proteinMpred, methylprednisoloneNP, NucleoproteinPCR, polymerase chain reactionPediatricPT, prothrombin timePTT, partial thromboplastin timeRBD, receptor binding domainSARS-CoV-2TE, thromboembolic eventsTNF, tumor necrosis factorTWEAK, TNF-like weak inducer of apoptosisU.S., United States of AmericaVA, veno-arterialVLPs, virus-like particlesVTE, venous thromboembolic events

Identifiers

PMID34121829
PMCPMC8179839
OpenAlexW3173061157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.