Evidence map›Paper›PMID 34121793›Full record

ArticleInverse problems2019

The influence of numerical error on parameter estimation and uncertainty quantification for advective PDE models.

John T Nardini, D M Bortz

Abstract read
In one paragraph

Article in Inverse problems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

John T NardiniStatistical and Applied Mathematical Sciences Institute, 4501 Research Commons, Suite 300 79 T.W. Alexander Drive, PO Box 110207 Durham, NC 27709, United States of America.ORCID 0000-0002-5503-1934
D M BortzDepartment of Applied Mathematics, University of Colorado, 526 UCB, Boulder, CO 80309-0526, United States of America.ORCID 0000-0003-1163-7317

Funding

Epithelial Cell Migration: Model selectionn for mechanistic model development R01GM126559 · NIGMS · UNIVERSITY OF COLORADO · PI BORTZ, DAVID · 2017 to 2021
$1.6M
NIGMS NIH HHS R01 GM126559
6 · The paper itself

Abstract

Advective partial differential equations can be used to describe many scientific processes. Two significant sources of error that can cause difficulties in inferring parameters from experimental data on these processes include (i) noise from the measurement and collection of experimental data and (ii) numerical error in approximating the forward solution to the advection equation. How this second source of error alters parameter estimation and uncertainty quantification during an inverse problem methodology is not well understood. As a step towards a better understanding of this problem, we present both analytical and computational results concerning how a least squares cost function and parameter estimator behave in the presence of numerical error in approximating solutions to the underlying advection equation. We investigate residual patterns to derive an autocorrelative statistical model that can improve parameter estimation and confidence interval computation for first order methods. Building on our results and their general nature, we provide guidelines for practitioners to determine when numerical or experimental error is the main source of error in their inference, along with suggestions of how to efficiently improve their results.

Indexed as

autocorrelationinverse problemsnumerical analysisuncertainty quantification

Identifiers

PMID34121793
PMCPMC8191598

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.