Evidence map›Paper›PMID 34121784›Full record

ArticleJournal of the American Statistical Association2021

Robust Q-learning.

Ashkan Ertefaie, James R McKay, David Oslin, Robert L Strawderman

Abstract read
In one paragraph

Article in Journal of the American Statistical Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Dynamic Treatment Regimes on Dyadic Networks.Statistics in medicine · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ashkan ErtefaieDepartment of Biostatistics and Computational Biology, University of Rochester.
James R McKayCenter on the Continuum of Care in the Addictions, Department of Psychiatry, University of Pennsylvania.
David OslinPhiladelphia Veterans Administration Medical Center, and Treatment Research Center and Center for Studies of Addictions, Department of Psychiatry, University of Pennsylvania.
Robert L StrawdermanDepartment of Biostatistics and Computational Biology, University of Rochester.

Funding

Analyzing Sequential, Multiple Assignment, Randomized Trials in the Presence of Partial ComplianceR01DA048764 · NIDA · UNIVERSITY OF ROCHESTER · PI ERTEFAIE, ASHKAN · 2019 to 2022
$1.6M
Advancing personalized medicine in PD using harmonized multi-site clinical dataR61NS120240 · NINDS · UNIVERSITY OF ROCHESTER · PI ERTEFAIE, ASHKAN, MCDERMOTT, MICHAEL P · 2020 to 2021
$1.1M
Optimal dynamic treatment strategies for controlling alcohol use: novel methods for selecting and incorporating effect modifiersR21AA027571 · NIAAA · UNIVERSITY OF ROCHESTER · PI ERTEFAIE, ASHKAN · 2019 to 2020
$423k
NIAAA NIH HHS R21 AA027571NIDA NIH HHS R01 DA048764NINDS NIH HHS R61 NS120240
6 · The paper itself

Abstract

Q-learning is a regression-based approach that is widely used to formalize the development of an optimal dynamic treatment strategy. Finite dimensional working models are typically used to estimate certain nuisance parameters, and misspecification of these working models can result in residual confounding and/or efficiency loss. We propose a robust Q-learning approach which allows estimating such nuisance parameters using data-adaptive techniques. We study the asymptotic behavior of our estimators and provide simulation studies that highlight the need for and usefulness of the proposed method in practice. We use the data from the "Extending Treatment Effectiveness of Naltrexone" multi-stage randomized trial to illustrate our proposed methods.

Indexed as

Cross-fittingData-adaptive techniquesDynamic treatment strategiesResidual confounding

Identifiers

PMID34121784
PMCPMC8190585

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.