Evidence map›Paper›PMID 34121452›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Skeletal myopathy in CKD: a comparison of adenine-induced nephropathy and 5/6 nephrectomy models in mice.

Kyoungrae Kim, Erik M Anderson, Trace Thome, Guanyi Lu, Zachary R Salyers, Tomas A Cort, Kerri A O'Malley, Salvatore T Scali, Terence E Ryan

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Kidney disease impairs tendon function in rats.The Journal of physiology · 2026
    Article
  11. Article
  12. Asiatic acid fromFrontiers in nutrition · 2026
    Article
  13. Review
  14. Article
  15. Article
  16. Article
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  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Kyoungrae KimDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida.
Erik M AndersonDivision of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Florida.
Trace ThomeDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida.
Guanyi LuDivision of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Florida.
Zachary R SalyersDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida.
Tomas A CortDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida.
Kerri A O'MalleyDivision of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Florida.
Salvatore T ScaliDivision of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville, Florida.
Terence E RyanDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida.ORCID 0000-0003-0780-029X
University of Florida · US

Funding

Molecular Biology in Burns and TraumaT32GM008721 · NIGMS · UNIVERSITY OF FLORIDA · PI Philip A Efron · 1999 to 2026
$5.0M
Molecular mechanisms regulating peripheral arterial disease pathobiology in chronic kidney diseaseR01HL149704 · NHLBI · UNIVERSITY OF FLORIDA · PI Terence E Ryan · 2020 to 2026
$3.6M
Impaired Mitochondrial Energetics is a Driver of Hemodialysis Access Related Hand DysfunctionR01HL148597 · NHLBI · UNIVERSITY OF FLORIDA · PI SCALI, SALVATORE T. · 2019 to 2023
$2.7M
NHLBI NIH HHS R01 HL148597NHLBI NIH HHS R01 HL149704NIGMS NIH HHS T32 GM008721
6 · The paper itself

Abstract

Preclinical animal models of chronic kidney disease (CKD) are critical to investigate the underlying mechanisms of disease and to evaluate the efficacy of novel therapeutics aimed to treat CKD-associated pathologies. The objective of the present study was to compare the adenine diet and 5/6 nephrectomy (Nx) CKD models in mice. Male and female 10-wk-old C57BL/6J mice (

Indexed as

AdenineAnimalsDisease Models, AnimalGlomerular Filtration RateKidneyMaleMiceMice, Inbred C57BLMuscle, SkeletalMuscular DiseasesNephrectomyRenal Insufficiency, ChronicUremiaAdenineatrophycachexiamitochondriarenaluremia

Identifiers

PMID34121452
PMCPMC8321803
OpenAlexW3166662757

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.