Evidence map›Paper›PMID 34121311›Full record

ArticleEMBO reports2021

RANKL from bone marrow adipose lineage cells promotes osteoclast formation and bone loss.

Yan Hu, Xiaoqun Li, Xin Zhi, Wei Cong, Biaotong Huang, Huiwen Chen, Yajun Wang, Yinghua Li, Lipeng Wang, Chao Fang and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 136 citations in OpenAlex.

  1. Article
  2. Review
  3. Marine drugs · 2026
    Article
  4. Review
  5. Youthfulness of marrow AdipoqBone research · 2026
    Article
  6. Article
  7. Review
  8. A RANKLBone research · 2026
    Article
  9. Article
  10. Article
  11. Bone matrix proteins: regulators of skeletal remodeling and repair.Journal of bone and mineral metabolism · 2026
    Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. The RANK/RANKL axis controls vascular dynamics in the bone marrow.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Review
  18. Review
  19. Article
  20. Review

36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Yan HuInstitute of Translational Medicine, Shanghai University, Shanghai, China.ORCID 0000-0002-9484-6546
Xiaoqun LiDepartment of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Xin ZhiDepartment of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Wei CongInstitute of Translational Medicine, Shanghai University, Shanghai, China.
Biaotong HuangInstitute of Translational Medicine, Shanghai University, Shanghai, China.
Huiwen ChenDepartment of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Yajun WangDepartment of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Yinghua LiInstitute of Translational Medicine, Shanghai University, Shanghai, China.
Lipeng WangGraduate Management Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Chao FangDepartment of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Jiawei GuoDepartment of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Ying LiuInstitute of Translational Medicine, Shanghai University, Shanghai, China.
Jin CuiDepartment of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Liehu CaoDepartment of Orthopedics Trauma, Shanghai Luodian Hospital, Shanghai, China.
Weizong WengDepartment of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Qirong ZhouDepartment of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.
Sicheng WangDepartment of Orthopedics Trauma, Shanghai Zhongye Hospital, Shanghai, China.ORCID 0000-0003-0001-9476
Xiao ChenDepartment of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China.ORCID 0000-0003-4517-0508
Jiacan SuInstitute of Translational Medicine, Shanghai University, Shanghai, China.ORCID 0000-0001-7080-263X
Second Military Medical University · CNShanghai University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Receptor activator of NF-κB ligand (RANKL) is essential for osteoclast formation and bone remodeling. Nevertheless, the cellular source of RANKL for osteoclastogenesis has not been fully uncovered. Different from peripheral adipose tissue, bone marrow (BM) adipose lineage cells originate from bone marrow mesenchymal stromal cells (BMSCs). Here, we demonstrate that adiponectin promoter-driven Cre expression (Adipoq

Indexed as

Bone ResorptionOsteoclastsAdipose TissueAnimalsBone MarrowBone Marrow CellsCell DifferentiationMicebone marrow adipose lineage cellbone remodelingosteoclastRANKL

Identifiers

PMID34121311
PMCPMC8406405
OpenAlexW3171465779

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.