Evidence map›Paper›PMID 34121130›Full record

SynthesisLangenbeck's archives of surgery2021

EUS-guided gastroenterostomy versus duodenal stent placement and surgical gastrojejunostomy for the palliation of malignant gastric outlet obstruction: a systematic review and meta-analysis.

Mateus Bond Boghossian, Mateus Pereira Funari, Diogo Turiani Hourneaux De Moura, Thomas R McCarty, Vitor Massaro Takamatsu Sagae, Yen-I Chen, Pastor Joaquín Ortiz Mendieta, Fernando Lopes Ponte Neto, Wanderley Marques Bernardo, Marcos Eduardo Lera Dos Santos and 3 more

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Langenbeck's archives of surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06071507 (Management of Malignant Gastric Outlet Obstruction Between Surgery and Endoscopy), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
12.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06071507 recruitingnot on this mapstarted 2024, after this paper: background citation

Management of Malignant Gastric Outlet Obstruction Between Surgery and Endoscopy

Typeobservational_patient_registrySponsorIRCCS San RaffaeleRan2024 to 2027Enrolled250ConditionsGastric Outlet Obstruction, Pancreatic Cancer
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.

  1. Pooled it
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  3. Partially covered versus uncovered pyloro-duodenal stents for unresectable malignant gastric outlet obstruction: Randomized controlled study.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2024
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  11. Endoscopic ultrasound-guided gastrojejunostomy with wire endoscopic simplified technique: Move towards benign indications (with video).Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Mateus Bond BoghossianGastrointestinal Endoscopy Unit, Universidade de São Paulo Hospital das Clínicas, Av. Dr Enéas de Carvalho Aguiar, 255. 6° andar, bloco 3, Cerqueira César, Sao Paulo, 05403-000, Brazil. mateus.boghossian@hc.fm.usp.br.ORCID http://orcid.org/0000-0002-2641-4952
Mateus Pereira FunariGastrointestinal Endoscopy Unit, Universidade de São Paulo Hospital das Clínicas, Av. Dr Enéas de Carvalho Aguiar, 255. 6° andar, bloco 3, Cerqueira César, Sao Paulo, 05403-000, Brazil.ORCID https://orcid.org/0000-0002-4828-9320
Diogo Turiani Hourneaux De MouraGastrointestinal Endoscopy Unit, Universidade de São Paulo Hospital das Clínicas, Av. Dr Enéas de Carvalho Aguiar, 255. 6° andar, bloco 3, Cerqueira César, Sao Paulo, 05403-000, Brazil.ORCID https://orcid.org/0000-0002-7446-0355
Thomas R McCartyDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0003-4517-5261
Vitor Massaro Takamatsu SagaeGastrointestinal Endoscopy Unit, Universidade de São Paulo Hospital das Clínicas, Av. Dr Enéas de Carvalho Aguiar, 255. 6° andar, bloco 3, Cerqueira César, Sao Paulo, 05403-000, Brazil.ORCID https://orcid.org/0000-0002-0441-8645
Yen-I ChenDivision of Gastroenterology and Hepatology, McGill University Health Center, Montreal, QC, Canada.ORCID https://orcid.org/0000-0001-5704-2226
Pastor Joaquín Ortiz MendietaGastrointestinal Endoscopy Unit, Universidade de São Paulo Hospital das Clínicas, Av. Dr Enéas de Carvalho Aguiar, 255. 6° andar, bloco 3, Cerqueira César, Sao Paulo, 05403-000, Brazil.ORCID https://orcid.org/0000-0002-0304-8005
Fernando Lopes Ponte NetoGastrointestinal Endoscopy Unit, Universidade de São Paulo Hospital das Clínicas, Av. Dr Enéas de Carvalho Aguiar, 255. 6° andar, bloco 3, Cerqueira César, Sao Paulo, 05403-000, Brazil.ORCID https://orcid.org/0000-0002-4545-030X
Wanderley Marques BernardoGastrointestinal Endoscopy Unit, Universidade de São Paulo Hospital das Clínicas, Av. Dr Enéas de Carvalho Aguiar, 255. 6° andar, bloco 3, Cerqueira César, Sao Paulo, 05403-000, Brazil.ORCID https://orcid.org/0000-0002-8597-5207
Marcos Eduardo Lera Dos SantosGastrointestinal Endoscopy Unit, Universidade de São Paulo Hospital das Clínicas, Av. Dr Enéas de Carvalho Aguiar, 255. 6° andar, bloco 3, Cerqueira César, Sao Paulo, 05403-000, Brazil.ORCID https://orcid.org/0000-0001-9759-3807
Filipe Tomishige ChavesRua Isabel Schmidt, Universidade Santo Amaro, 349 - Santo Amaro, São Paulo, SP, 04743-030, Brazil.
Mouen A KhashabDivision of Gastroenterology and Hepatology, Johns Hopkins Medicine, Baltimore, MD, USA.
Eduardo Guimarães Hourneaux de MouraGastrointestinal Endoscopy Unit, Universidade de São Paulo Hospital das Clínicas, Av. Dr Enéas de Carvalho Aguiar, 255. 6° andar, bloco 3, Cerqueira César, Sao Paulo, 05403-000, Brazil.ORCID https://orcid.org/0000-0002-8023-3722
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRBrigham and Women's Hospital · USJohns Hopkins University · USMcGill University Health Centre · CAUniversidade de Santo Amaro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeMalignant gastric outlet obstruction (GOO) is associated with significant morbidity and decreased quality of life, thereby necessitating effective and safe palliative treatment. As such, we sought to compare endoscopic ultrasound-guided gastroenterostomy (EUS-GE) versus duodenal stent (DS) placement and surgical gastrojejunostomy (SGJ) for palliation of malignant GOO.

methodsSearches of electronic databases were performed to identify studies comparing EUS-GE versus DS and/or SGJ for palliative treatment of GOO. Outcomes included technical and clinical success, severe adverse events (SAEs), rate of stent obstruction (including tumor ingrowth), length of hospital stay (LOS), reintervention, and 30-day all-cause mortality. Differences in dichotomous and continuous outcomes were reported as risk difference and mean difference, respectively.

resultsSeven studies (n = 513 patients) were included. When compared to DS placement, EUS-GE was associated with a higher clinical success, fewer SAEs, decreased stent obstruction, lower rate of tumor ingrowth, and decreased need for reintervention. Compared to SGJ, EUS-GE was associated with a lower technical success; however, LOS was significantly decreased. All other outcomes including clinical success, SAEs, reintervention rate, and 30-day mortality were not significantly different between an EUS-guided versus surgical approach.

conclusionsEUS-GE was associated with significantly improved outcomes compared to DS placement for palliative treatment of malignant GOO. Despite SGJ possessing a higher technical success compared to EUS-GE, LOS was significantly longer with no difference in clinical success or rate of adverse events.

Indexed as

Gastric BypassGastric Outlet ObstructionGastroenterostomyHumansPalliative CareQuality of LifeStentsUltrasonography, InterventionalDuodenal stentGastric outlet obstructionLumen-apposing metal stentSurgical gastroenterostomyTherapeutic endoscopic ultrasound

Identifiers

PMID34121130
OpenAlexW3166916426

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.