ArticleJournal of Alzheimer's disease : JAD2021
Time to Diagnosis in Young Onset Alzheimer's Disease: A Population-Based Study from Central Norway.
Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Systematic Review of the Needs of Children and Young People of a Parent Diagnosed With Young-Onset-Dementia: Informing a Nursing Intervention.Journal of advanced nursing · 2026Pooled it
- Time to Diagnosis in Dementia: A Systematic Review With Meta-Analysis.International journal of geriatric psychiatry · 2025Pooled it
- Machine Learning-Based Cognitive Assessment With The Autonomous Cognitive Examination: Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Diagnostic delay in early-onset Alzheimer's disease in Japan: a retrospective study.BMC neurology · 2026Observational
- Morbidity and medication use preceding a diagnosis of late-onset Alzheimer's disease: a Danish nationwide study.Journal of neurology · 2026Article
- Clinical characteristics and neuropsychiatric profiles of young-onset dementia: a retrospective cross-sectional study at a tertiary care center in Northern Thailand.Frontiers in psychiatry · 2026Article
- A Unified Continuous Staging Framework for Alzheimer's Disease and Lewy Body Dementia via Hierarchical Anatomical Features.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026Article
- Real-world prediction of early-onset dementia by health record data: A multi-center machine learning study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The Rapid Online Cognitive Assessment for the Detection of Neurocognitive Disorder: Open-Label Study.Journal of medical Internet research · 2025Article
- Navigating the introduction of anti-amyloid therapy in Europe: a position statement by individual members of the EADC.Alzheimer's research & therapy · 2025Review
- Comment on "Associations of semaglutide with first-time diagnosis of Alzheimer's disease in patients with type 2 diabetes: Target trial emulation using nationwide real-world data in the US".Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Exploring the Delivery and Management of Specialised Post-Diagnostic Care and Support in Young-Onset Dementia: A Cross-Sectional Study.Health services insights · 2025Article
- Navigating the Alzheimer's Biomarker Landscape: A Comprehensive Analysis of Fluid-Based Diagnostics.Cells · 2024Review
- Creating and Reliving the Moment: Using Musical Improvisation and Care Aesthetics as a Lens of Connection and Self-Expression for Younger People Living with Dementia.International journal of environmental research and public health · 2024Article
- Promising brain biodistribution of insulin via intranasal dry powder for nose-to-brain delivery.Heliyon · 2024Article
- Prescription medication use in the 10 years prior to diagnosis of young onset Alzheimer's disease: a nationwide nested case-control study.Alzheimer's research & therapy · 2024Article
- Post-diagnostic support for persons with young-onset dementia - a retrospective analysis based on data from the Swedish dementia registry SveDem.BMC health services research · 2024Article
- Incremental value of amyloid PET in a tertiary memory clinic setting in China.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Mapping morbidity 10 years prior to a diagnosis of young onset Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Clinical profile and survival analysis of Alzheimer's disease patients in a Brazilian cohort.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundYoung onset dementia is associated with a longer time to diagnosis compared to late onset dementia. Earlier publications have indicated that atypical presentation is a key contributing factor to the diagnostic delay. Our hypothesis was that even the most common presentation of Alzheimer's disease is associated with a substantial diagnostic delay in patients < 65 years.
objectiveTo determine the time to diagnosis, and time lags in the diagnostic pathway in typical young onset Alzheimer's disease in central Norway.
methodsThe main sources of patients were the databases at the Department of Neurology, University Hospital of Trondheim (St. Olav's Hospital), and Department of Psychiatry, Levanger Hospital. Other sources included key persons in the communities, collaborating hospital departments examining patients with suspected cognitive impairment, and review of hospital records of all three hospitals in the area. Information on the time lags, and the clinical assessment, including the use of biomarkers, was collected from hospital notes. Caregivers were interviewed by telephone.
resultsTime from first symptom to diagnosis in typical young onset Alzheimer's disease was 5.5 years (n = 223, SD 2.8). Time from onset to contact with healthcare services (usually a general practitioner) was 3.4 years (SD 2.3). Time from contact with healthcare services to the first visit at a hospital was 10.3 months (SD 15.5). Time from first visit at a hospital to diagnosis was 14.8 months (SD 22.6). The analysis of cerebrospinal fluid core biomarkers was performed after 8.3 months (SD 20.9).
conclusionTypical Alzheimer's disease is associated with a substantial diagnostic delay in younger patients. Raising public awareness, and education of healthcare professionals on the aspects of young onset Alzheimer's disease is warranted. CSF core biomarkers should be performed earlier in the hospital evaluation process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.