ArticleMayo Clinic proceedings2021
Cost-Related Nonadherence to Medications Among US Adults With Chronic Liver Diseases.
Article in Mayo Clinic proceedings, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Financial burden among liver transplant candidates is associated with financial distress and work impairment: A U.S. multicenter study.Hepatology communications · 2026Article
- Association between Difficulty Affording Medications and Outcomes in Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2025Article
- Changes in cost-related nonadherence among US adults with multiple chronic conditions from 2019 to 2023.Journal of managed care & specialty pharmacy · 2025Article
- Non-monetary burdens of out-of-pocket costs incurred by patients and caregivers for medical care: a scoping review.BMJ open · 2025Article
- Increasing Healthcare System Empathy for Patients with Advanced Liver Disease: My Top 10 Lessons in Palliative Hepatology.Digestive diseases and sciences · 2024Article
- Cost-related medication nonadherence in adults with COPD in the United States 2013-2020.BMC public health · 2024Article
- Health care-related transportation insecurity is associated with adverse health outcomes among adults with chronic liver disease.Hepatology communications · 2024Article
- In the wake of a crisis: Caught between housing and healthcare.SSM - population health · 2023Article
- Healthcare affordability and effects on mortality among adults with liver disease from 2004 to 2018 in the United States.Journal of hepatology · 2023Article
- Low Prevalence of Use of Allied Health and Community Services for Patients with Cirrhosis in Australia: A Need for Greater Engagement.Patient preference and adherence · 2023Article
- Real price of health-experiences of out-of-pocket costs in Australia: protocol for a systematic review.BMJ open · 2022Article
- AASLD Practice Guidance: Palliative care and symptom-based management in decompensated cirrhosis.Hepatology (Baltimore, Md.) · 2022Article
- The Impact of Social Workers in Cirrhosis Care: a Systematic Review.Current treatment options in gastroenterology · 2022Review
- Increasing pharmacoequity for people with cirrhosis.Clinical liver diseaseReview
- Sociodemographic disparities in documented nonadherence to medication for hepatic encephalopathy: a National Inpatient Sample analysis.Annals of gastroenterologyArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo estimate the prevalence, risk factors, and consequences of cost-related medication nonadherence (CRN) in individuals with chronic liver diseases (CLDs) in the United States. PATIENTS AND
methodsUsing the National Health Interview Survey from January 1, 2014, to December 31, 2018, we identified individuals with CLDs. Using complex weighted survey analysis, we obtained national estimates and risk factors for CRN and its association with cost-reducing behaviors and measures of financial toxicity. We evaluated the association of CRN with unplanned health care use, adjusting for age, sex, race/ethnicity, insurance, income, education, and comorbid conditions.
resultsOf 3237 respondents (representing 4.6 million) US adults with CLDs, 813 (representing 1.2 million adults, or 25%; 95% CI, 23% to 27%) reported CRN, of whom 68% (n=554/813) reported maladaptive cost-reducing behaviors. Younger age, female sex, low income, and multimorbidity were associated with a higher prevalence of CRN. Compared with patients without CRN, patients experiencing CRN had 5.1 times higher odds of financial hardship from medical bills (adjusted odds ratio [aOR], 5.05; 95% CI, 3.73 to 6.83) and 2.9 times higher odds of food insecurity (aOR, 2.85; 95% CI, 2.02 to 4.01). The CRN was also associated with 1.5 times higher odds of emergency department visits (aOR, 1.46; 95% CI, 1.11 to 1.94).
conclusionWe observed a high prevalence of CRN and associated consequences such as high financial distress, financial hardship from medical bills, food insecurity, engagement in maladaptive cost-reducing strategies, increased health care use, and work absenteeism among patients with CLD. These financial determinants of health have important implications in the context of value-based care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.