SynthesisBMC emergency medicine2021
Predicting mortality in adult patients with sepsis in the emergency department by using combinations of biomarkers and clinical scoring systems: a systematic review.
Synthesis in BMC emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Prognostic models for predicting intensive care unit admission or mortality in critically ill adults not yet been admitted to the intensive care unit.The Cochrane database of systematic reviews · 2026Pooled it
- Clinical Performance of BIO-S and BIO-SC Composite Bioscores for 28-Day Mortality Stratification in Adults with Sepsis and Septic Shock.Biomedicines · 2026Article
- Diagnostic Value of End-Tidal Carbon Dioxide Combined With Lactate for Early Detection of Sepsis in Prehospital Patients: A Prospective Cohort Study.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Soluble Urokinase Plasminogen Activator Receptor (suPAR): Role in the Risk Stratification of Potentially Infected Patients Presenting at the Emergency Department.Diagnostics (Basel, Switzerland) · 2026Article
- Assessment of Systemic Inflammation as a Tool for Estimating the Risk of Death by Visceral Leishmaniasis.Pathogens (Basel, Switzerland) · 2026Article
- Risk factor analysis and nomogram model construction for mortality in patients following colonic perforation surgery.World journal of gastrointestinal surgery · 2026Article
- Elevated baseline vitamin B12 level and all-cause mortality risk in patients with sepsis: a cohort analysis.Frontiers in nutrition · 2026Article
- Prognostic nutritional index, Naples prognostic score and Osaka prognostic score as predictors of acute respiratory distress syndrome in non-diabetes mellitus patients with sepsis: a loss of predictive efficacy of NPS and OPS in diabetes mellitus cohorts.Frontiers in endocrinology · 2026Article
- Group-based trajectory modeling of anion gap and mortality in patients with sepsis: a retrospective analysis of the MIMIC-IV database.European journal of medical research · 2025Article
- Automated sepsis prediction from unstructured electronic health records using natural language processing: a retrospective cohort study.BMJ health & care informatics · 2025Article
- Human neutrophil lipocalin, procalcitonin, c-reactive protein, and leucocyte count for prediction of bacterial sepsis in emergency department patients.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Evaluation of the Diagnosis and Antibiotic Therapy of Sepsis in the Emergency Department: A Retrospective Observational Study.Biomedicines · 2025Article
- Bio-Adrenomedullin and Dipeptidyl Peptidase 3 as Novel Sepsis Biomarkers in the Emergency Department and the Intensive Care Unit: A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Comparison of Standardized Mortality Ratios in seven Dutch EDs based on presenting complaints.BMC emergency medicine · 2025Observational
- Interpretable Machine Learning Model for Early Mortality Prediction in Septic Patients Using Routine Post-Diagnosis Clinical Data: A Multicenter Study.Journal of inflammation research · 2025Article
- Article
- Development and validation of mortality risk prediction model for sepsis secondary to pneumonia at intensive care unit admission: a retrospective case-cohort study.Frontiers in medicine · 2025Article
- Early Mortality Prediction in Intensive Care Unit Patients Based on Serum Metabolomic Fingerprint.International journal of molecular sciences · 2024Article
- Combining host immune response biomarkers and clinical scores for early prediction of sepsis in infection patients.Annals of medicine · 2024Article
- Early Mortality Stratification with Serum Albumin and the Sequential Organ Failure Assessment Score at Emergency Department Admission in Septic Shock Patients.Life (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis can be detected in an early stage in the emergency department (ED) by biomarkers and clinical scoring systems. A combination of multiple biomarkers or biomarker with clinical scoring system might result in a higher predictive value on mortality. The goal of this systematic review is to evaluate the available literature on combinations of biomarkers and clinical scoring systems on 1-month mortality in patients with sepsis in the ED.
methodsWe performed a systematic search using MEDLINE, EMBASE and Google Scholar. Articles were included if they evaluated at least one biomarker combined with another biomarker or clinical scoring system and reported the prognostic accuracy on 28 or 30 day mortality by area under the curve (AUC) in patients with sepsis. We did not define biomarker cut-off values in advance.
resultsWe included 18 articles in which a total of 35 combinations of biomarkers and clinical scoring systems were studied, of which 33 unique combinations. In total, seven different clinical scoring systems and 21 different biomarkers were investigated. The combination of procalcitonin (PCT), lactate, interleukin-6 (IL-6) and Simplified Acute Physiology Score-2 (SAPS-2) resulted in the highest AUC on 1-month mortality.
conclusionThe studies we found in this systematic review were too heterogeneous to conclude that a certain combination it should be used in the ED to predict 1-month mortality in patients with sepsis. Future studies should focus on clinical scoring systems which require a limited amount of clinical parameters, such as the qSOFA score in combination with a biomarker that is already routinely available in the ED.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.