Evidence map›Paper›PMID 34120577›Full record

ArticleEmerging microbes & infections2021

Potent RBD-specific neutralizing rabbit monoclonal antibodies recognize emerging SARS-CoV-2 variants elicited by DNA prime-protein boost vaccination.

Yuxin Chen, Liguo Zhu, Weijin Huang, Xin Tong, Hai Wu, Yue Tao, Bei Tong, Haibin Huang, Jiachen Chen, Xiangan Zhao and 2 more

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
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  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. The immunology and immunotherapy for COVID-19.Expert reviews in molecular medicine · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 3 countries.

Yuxin ChenDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, People's Republic of China.
Liguo ZhuJiangsu Provincial Center for Disease Control and Prevention, Nanjing, People's Republic of China.
Weijin HuangDivision of HIV/AIDS and Sex-Transmitted Virus Vaccines, Institute for Biological Product Control, National Institute for Food and Drug Control, Beijing, People's Republic of China.
Xin TongDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, People's Republic of China.
Hai WuYurogen Biosystem LLC, Worcester, MA, USA.
Yue TaoDepartment of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, People's Republic of China.
Bei TongInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, People's Republic of China.
Haibin HuangYurogen Biosystem LLC, Worcester, MA, USA.
Jiachen ChenYurogen Biosystem LLC, Worcester, MA, USA.
Xiangan ZhaoDepartment of Gastroenterology, Northern Jiangsu People's Hospital, Clinical Medical College of Yangzhou University, Yangzhou, People's Republic of China.
Yang LouYurogen Biosystem LLC, Worcester, MA, USA.
Chao WuDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, People's Republic of China.
Reprogenetics · USNanjing Drum Tower Hospital · CNBioSystem (Germany) · DEInstitute of Botany · CNJiangsu Provincial Center for Disease Control and Prevention · CNNanjing Medical University · CNNanjing University · CNNational Institutes for Food and Drug Control · CNYangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Global concerns arose as the emerged and rapidly spreading SARS-CoV-2 variants might escape host immunity induced by vaccination. In this study, a heterologous prime-boost immunization strategy for COVID-19 was designed to prime with a DNA vaccine encoding wild type (WT) spike protein receptor-binding domain (RBD) followed by S1 protein-based vaccine in rabbits. Four vaccine-elicited rabbit monoclonal antibodies (RmAbs), including 1H1, 9H1, 7G5, and 5E1, were isolated for biophysical property, neutralization potency and sequence analysis. All RmAbs recognized RBD or S1 protein with K

Indexed as

Genetic VariationAnimalsAntibodies, NeutralizingAntibodies, ViralEpitopesHumansImmunization, SecondaryProtein DomainsRabbitsSARS-CoV-2Spike Glycoprotein, CoronavirusVaccinationVaccines, DNAVaccines, SyntheticVirus AttachmentAntibodies, NeutralizingAntibodies, ViralEpitopesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Vaccines, DNAVaccines, Syntheticrabbit mAbSARS-CoV-2vaccinevariant of concerns

Identifiers

PMID34120577
PMCPMC8274519
OpenAlexW3171369020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.