Evidence map›Paper›PMID 34120450›Full record

ArticleHypertension (Dallas, Tex. : 1979)2021

MicroRNA 379 Regulates Klotho Deficiency-Induced Cardiomyocyte Apoptosis Via Repression of Smurf1.

Kai Chen, Bo Zhang, Zhongjie Sun

Open access · bronzeAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Fibulin 2 Deficiency Drives Epigenetic Hypertension.Hypertension (Dallas, Tex. : 1979) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. MicroRNA-195a-5p Regulates Blood Pressure by Inhibiting NKCC2A.Hypertension (Dallas, Tex. : 1979) · 2023
    Article
  10. Review
  11. Review
  12. Article
  13. Stem cell therapy for pulmonary arterial hypertension: An update.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022
    Review
  14. In Vivo Cardiac-specific Expression of Adenylyl Cyclase 4 Gene Protects against Klotho Deficiency-induced Heart Failure.Translational research : the journal of laboratory and clinical medicine · 2022
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kai ChenFrom the Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis (K.C., B.Z., Z.S.).
Bo ZhangFrom the Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis (K.C., B.Z., Z.S.).
Zhongjie SunFrom the Department of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis (K.C., B.Z., Z.S.).
University of Tennessee Health Science Center · US

Funding

Investigation into Heart AgingR01AG049780 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SUN, ZHONGJIE · 2016 to 2020
$2.4M
Epigenetic Regulation of Kidney Function and Blood PressureR01AG062375 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SUN, ZHONGJIE · 2019 to 2023
$2.3M
Investigation into Arterial Stiffness and HypertensionR01HL154147 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SUN, ZHONGJIE · 2020 to 2023
$2.2M
Molecular Mechanism of Kidney AgingR01DK093403 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI SUN, ZHONGJIE · 2012 to 2016
$1.6M
Anti-aging gene klotho: a novel therapeutic target in calcific aortic valve diseaseR01HL118558 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SUN, ZHONGJIE · 2014 to 2017
$1.5M
NHLBI NIH HHS R01 HL118558NHLBI NIH HHS R01 HL154147NIA NIH HHS R01 AG049780NIA NIH HHS R01 AG062375NIDDK NIH HHS R01 DK093403
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AnimalsApoptosisCell LineKlotho ProteinsMiceMice, TransgenicMicroRNAsMyocytes, CardiacRatsUbiquitin-Protein LigasesKlotho ProteinsMicroRNAsSmurf1 protein, mouseUbiquitin-Protein Ligasesapoptosiscardiovascular diseaseheart failuremorbidityphosphate

Identifiers

PMID34120450
PMCPMC8285029
OpenAlexW3171239403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.