Observational studyJournal of the American Heart Association2021
Cumulative Serum Uric Acid and Its Time Course Are Associated With Risk of Myocardial Infarction and All-Cause Mortality.
Observational study in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Relation of serum uric acid with the risk of coronary heart disease: an updated systematic review and dose-response meta-analysis of epidemiologic studies.Frontiers in endocrinology · 2026Pooled it
- Association of serum uric acid with prognosis in patients with myocardial infarction: an update systematic review and meta-analysis.BMC cardiovascular disorders · 2023Pooled it
- Correlation between Running Average of Serum Uric Acid Levels and Clinical Course in Secondary Prevention of Coronary Artery Disease.Internal medicine (Tokyo, Japan) · 2026Article
- Serum uric acid and the trajectory of cardiometabolic multimorbidity: a prospective study conducted with data from the UK Biobank.Nutrition journal · 2026Article
- Independent and synergistic associations of cumulative body roundness index and its variability with fragility fracture risk.Lipids in health and disease · 2026Article
- Comparative associations of cumulative cholesterol-HDL-glucose index and triglyceride-glucose index with risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: a prospective cohort study.Frontiers in endocrinology · 2026Article
- Association Between Time-Averaged Serum Uric Acid Level and Subsequent Renal Involvement in Premenopausal Patients with Systemic Lupus Erythematosus.Archives of rheumatology · 2025Article
- Uric acid-to-albumin ratio × monocyte-to-lymphocyte ratio is a novel biomarker for predicting all-cause mortality and cardiovascular mortality in patients with ST-segment elevation myocardial infarction.Coronary artery disease · 2025Article
- Higher serum uric acid levels and risk of all-cause mortality in general population: a systematic review and meta-analysis.Metabolism open · 2025Article
- Association of Cumulative Exposure to Metabolic Score for Visceral Fat With the Risk of Cardiovascular Disease and All-Cause Mortality: A Prospective Cohort Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Association between onset age and mortality gradients in advanced cardiovascular-kidney-metabolic syndrome.Frontiers in endocrinology · 2025Observational
- The Role of Hyperuricemia in Cardiac Diseases: Evidence, Controversies, and Therapeutic Strategies.Biomolecules · 2024Review
- Distinct uric acid trajectories are associated with incident cardiac conduction block.Arthritis research & therapy · 2024Article
- Magnitude and time course of insulin resistance accumulation with the risk of cardiovascular disease: an 11-years cohort study.Cardiovascular diabetology · 2023Article
- Association of serum uric acid with all-cause and cardiovascular mortality in obstructive sleep apnea.Scientific reports · 2023Article
- URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease.iScience · 2023Article
- Separate and Joint Associations of Remnant Cholesterol Accumulation and Variability With Carotid Atherosclerosis: A Prospective Cohort Study.Journal of the American Heart Association · 2023Article
- Long-term cumulative high-sensitivity cardiac troponin T and mortality among patients with acute heart failure.ESC heart failure · 2023Article
- Association between cumulative uric acid to high-density lipoprotein cholesterol ratio and the incidence and progression of chronic kidney disease.Frontiers in endocrinology · 2023Article
- Time course of the triglyceride glucose index accumulation with the risk of cardiovascular disease and all-cause mortality.Cardiovascular diabetology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Serum uric acid (SUA) has been demonstrated as a risk factor for myocardial infarction (MI) and all-cause mortality; however, the impact of cumulative SUA (cumSUA) remains unclear. We aimed to investigate the association of cumSUA with MI risk and all-cause mortality, and to further explore the effects of SUA accumulation time course. Methods and Results The study enrolled 53 463 participants without a history of MI, and these participants underwent 3 examinations during 2006 to 2010. cumSUA from baseline to the third examination was calculated, multiplying mean values between consecutive examinations by time intervals between visits. Cox models estimated hazard ratios (HRs) and 95% CIs of MI and all-cause mortality for cumSUA quartiles, hyperuricemia exposure duration, and SUA accumulation time course. During a median follow-up of 7.04 years, 476 incident MIs and 2692 deaths occurred. In the fully adjusted model, a higher MI risk was observed in the highest cumSUA quartile (HR, 1.48; 95% CI, 1.10-1.99), in participants with longer hyperuricemia exposure duration (HR, 1.71; 95% CI, 1.06-2.73), and in participants with cumSUA≥median and a negative slope (HR, 1.58; 95% CI, 1.18-2.11). Similar associations persisted for all-cause mortality. Conclusions The risk of MI and all-cause mortality increased with higher cumSUA and was affected by the SUA accumulation time course. Early SUA accumulation contributed more to MI risk and all-cause mortality than later SUA accumulation with the same overall cumulative exposure, emphasizing the importance of optimal SUA control early in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.