ArticleAlcoholism, clinical and experimental research2021
Altered effective connectivity of the reward network during an incentive-processing task in adults with alcohol use disorder.
Article in Alcoholism, clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Aberrant cortico-striato-limbic functional connectivity to alcohol cues in co-occurring bipolar disorder and alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Characterizing the co-occurrence of alcohol experimentation and suicidal thoughts and behaviors in early adolescence.Translational psychiatry · 2026Article
- High Risk For High Reward? Latent Profiles Of Impulsivity and Reward Sensitivity in Relation to Alcohol Use Outcomes Among College Students.Personality and individual differences · 2025Article
- ExoTMS transcranial magnetic stimulation for the reduction of binge eating symptoms.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Altered effective connectivity of emotion perception and regulation networks during an emotional face perception task in adults with alcohol use disorder.Brain structure & function · 2025Article
- Trialing addiction neurocircuitry targets and directionality of brain stimulation effects: A deep TMS/fMRI trial in people with alcohol use disorder.Contemporary clinical trials communications · 2025Article
- Altered Effective Connectivity During Threat Anticipation in Individuals With Alcohol Use Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Impact of data processing varieties on DCM estimates of effective connectivity from task-fMRI.Human brain mapping · 2024Article
- People who binge drink show neuroendocrine tolerance to alcohol cues that is associated with immediate and future drinking- results from a randomized clinical experiment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Blunted neural reward response to alcohol and greater alcohol motivation in binge drinkers in a randomized clinical experiment.Alcohol, clinical & experimental research · 2023Article
- Differentiating Individuals with and without Alcohol Use Disorder Using Resting-State fMRI Functional Connectivity of Reward Network, Neuropsychological Performance, and Impulsivity Measures.Behavioral sciences (Basel, Switzerland) · 2022Article
- Functional Domains of Substance Use and their Implications to Trauma: A Systematic Review of Neuroimaging Studies.Chronic stress (Thousand Oaks, Calif.)Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAbnormalities of reward sensitivity and impulsivity are known to be correlated with each other and alcohol use disorder (AUD) risk, but the underlying aberrant neural circuitry involved is not clearly defined. We sought to extend the current knowledge of AUD pathophysiology by studying incentive processing in persons with AUD using functional neuroimaging data.
methodsWe utilized functional MRI data from the Human Connectome Project Database obtained during performance of a number-guessing incentive-processing task with win, loss, and neutral feedback conditions in 78 participants with either DSM-IV alcohol abuse or dependence (combined as the AUD group) and 78 age- and sex-matched control (CON) participants. Within a network consisting of anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), insula, ventral striatum, and dorsal striatum (DS) in the right hemisphere, we performed dynamic causal modeling analysis to test group-level differences (AUD vs. CON) in effective directional connectivity (EC) as modulated by "win" and "loss" conditions. We used linear regression analyses to characterize the relations between each EC outcome and measures of cumulative alcohol exposure and impulsivity.
resultsDuring wins, AUD participants had lower ECs from ACC to the other four nodes, greater ECs from insula to the other four nodes, greater ECs from DLPFC to the other four nodes, and greater DS to DS self-connection EC than CON participants. In the total sample, EC from the insula to the DLPFC (insula → DLPFC) during wins was positively correlated with both impulsivity (as measured by the delay-discounting task) and cumulative alcohol exposure. The DS to DS self-connection EC during wins was positively correlated with impulsivity. Many of the altered ECs from the ACC and insula to other nodes were correlated with cumulative alcohol exposure.
conclusionsIndividuals with AUD have disrupted EC in both instrumentally driven and automatized corticostriatal reward circuits during non-alcohol reward feedback. These results point to disrupted corticostriatal EC in both "top-down" and "bottom-up" pathways among individuals with AUD.
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