Evidence map›Paper›PMID 34120320›Full record

ArticleCell biochemistry and biophysics2021

Sec62 promotes pro-angiogenesis of hepatocellular carcinoma cells under hypoxia.

Yongbin Meng, Hetong Zhao, Zhihao Zhao, Zifei Yin, Zhe Chen, Juan Du

Abstract read
PubMed Publisher
In one paragraph

Article in Cell biochemistry and biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
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  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yongbin Meng *Department of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China.
Hetong Zhao *Department of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China.
Zhihao ZhaoDepartment of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China.
Zifei YinDepartment of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China.
Zhe ChenDepartment of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China.
Juan DuDepartment of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai, China. dujuan714@smmu.edu.cn.ORCID http://orcid.org/0000-0002-5068-3992
Second Military Medical University · CN

Funding

National Natural Science Foundation of China 81473487
6 · The paper itself

Abstract

This study aimed to investigate the underlying molecular pathogenic mechanism of Sec62 in hepatocellular carcinoma (HCC). Microarray analysis was conducted to profile the global gene expression in the HCC cell line Huh7 cells transfected with Sec62

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsNeovascularization, PathologicSignal TransductionCell HypoxiaCell Line, TumorGene Expression Regulation, NeoplasticHumansHuman Umbilical Vein Endothelial CellsPlasminogen Activator Inhibitor 1Protein Interaction MapsSerpin E2Tumor Suppressor Protein p53Plasminogen Activator Inhibitor 1SERPINE1 protein, humanSerpin E2Tumor Suppressor Protein p53AngiogenesisHepatocellular carcinomaHypoxiaPAI-1Sec62

Identifiers

PMID34120320
OpenAlexW3166460366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.