Evidence map›Paper›PMID 34120225›Full record

ArticleJournal of neurology2022

Morning light therapy in adults with Tourette's disorder.

Emily J Ricketts, Helen J Burgess, Gabrielle E Montalbano, Meredith E Coles, Joseph F McGuire, Hardian Thamrin, Dana L McMakin, James T McCracken, Mary A Carskadon, John Piacentini and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Bright light therapy for CPAP-resistant OSA symptoms.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Trial
  4. Trial
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Tourette disorder and sleep.Biomedical journal · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Emily J RickettsDepartment of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plz, Los Angeles, CA, 90024, USA. ERicketts@mednet.ucla.edu.ORCID http://orcid.org/0000-0002-1633-8618
Helen J BurgessDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-3816-8194
Gabrielle E MontalbanoDepartment of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plz, Los Angeles, CA, 90024, USA.
Meredith E ColesDepartment of Psychology, State University of New York At Binghamton, Binghamton, NY, USA.ORCID http://orcid.org/0000-0003-3243-0593
Joseph F McGuireDepartment of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-6128-8138
Hardian ThamrinDepartment of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plz, Los Angeles, CA, 90024, USA.ORCID http://orcid.org/0000-0001-9013-6507
Dana L McMakinDepartment of Psychology, Florida International University, Miami, FL, USA.ORCID http://orcid.org/0000-0002-6954-4204
James T McCrackenDepartment of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plz, Los Angeles, CA, 90024, USA.ORCID http://orcid.org/0000-0003-0370-0777
Mary A CarskadonDepartment of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA.ORCID http://orcid.org/0000-0001-7240-0140
John PiacentiniDepartment of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plz, Los Angeles, CA, 90024, USA.ORCID http://orcid.org/0000-0003-4195-7194
Christopher S ColwellDepartment of Psychiatry and Biobehavioral Sciences, University of California, 760 Westwood Plz, Los Angeles, CA, 90024, USA.ORCID http://orcid.org/0000-0002-1059-184X
Neurobehavioral Systems · USBinghamton University · USBrown University · USFlorida International University · USJohns Hopkins University · USUniversity of Michigan · US

Funding

TRAINING THE SCIENCE OF CHILD MENTAL HEALTH TREATMENTT32MH073517 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMA JACOB, John C. Piacentini · 2006 to 2026
$5.2M
Investigating Circadian Rhythms in Youth with Persistent Tic DisordersK23MH113884 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RICKETTS, EMILY JULIA · 2017 to 2022
$992k
NIMH NIH HHS K23 MH113884NIMH NIH HHS K23MH113884NIMH NIH HHS T32 MH073517NIMH NIH HHS T32MH073517
6 · The paper itself

Abstract

backgroundSleep disturbance is common among individuals with Tourette's Disorder (TD). Given that sleep is influenced by the circadian system, this study examined circadian rhythms and sleep in adults with TD, and explored the possible benefit of short-wavelength wearable morning light therapy.

methodsParticipants were 34 adults with TD (n = 14) and age- and sex-matched healthy controls (HC; n = 20). Participants were screened using clinician-rated diagnostic and tic severity interviews, and procedures lasted 3 consecutive weeks. Participants completed a baseline week of actigraphy. Adults with TD completed 2 weeks of Re-Timer™ morning light therapy and continued actigraphy monitoring. Dim light melatonin-onset (DLMO) phase assessment, tic severity interview, and measures of chronotype, sleep disturbance, daytime sleepiness, disability, depression, anxiety, and stress were completed at baseline and post-intervention.

resultsAdults with TD reported significantly greater eveningness and sleep disturbance relative to controls. Per wrist actigraphy, adults with TD exhibited significantly longer sleep-onset latency, lower sleep efficiency, and greater sleep fragmentation than HC. Following morning light therapy, there was a significant advance in DLMO phase, but not self-report or actigraphy sleep variables. There were small, statistically significant decreases in tic severity and impairment. There were also significant reductions in daytime sleepiness, and self-reported anxiety, but not depression, stress, or disability. Participants reported minimal side effects and rated light therapy as acceptable and comfortable.

conclusionsFindings showed some benefits following brief light therapy in TD; further exploration of the impact of spectral tuning the photic environment as part of treatment for TD subjects is warranted.

Indexed as

Tourette SyndromeActigraphyAdultCircadian RhythmHumansPhototherapySleepActigraphyAnxietyChronotypeCircadianDepressionMelatoninSleepSleepinessTic

Identifiers

PMID34120225
PMCPMC8666462
OpenAlexW3168840582

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.