Evidence map›Paper›PMID 34120215›Full record

ReviewEuropean biophysics journal : EBJ2022

The role of physical cues in the development of stem cell-derived organoids.

Ilaria Tortorella, Chiara Argentati, Carla Emiliani, Sabata Martino, Francesco Morena

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European biophysics journal : EBJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
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  16. Tumor Organoid as a Drug Screening Platform for Cancer Research.Current stem cell research & therapy · 2024
    Review
  17. Skeletal organoids.Biomaterials translational · 2024
    Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ilaria Tortorella *Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, 06123, Perugia, Italy.
Chiara Argentati *Department of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, 06123, Perugia, Italy.
Carla EmilianiDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, 06123, Perugia, Italy.
Sabata MartinoDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, 06123, Perugia, Italy. sabata.martino@unipg.it.ORCID http://orcid.org/0000-0002-3942-237X
Francesco MorenaDepartment of Chemistry, Biology and Biotechnology, University of Perugia, Via del Giochetto, 06123, Perugia, Italy. francesco.morena@unipg.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organoids are a novel three-dimensional stem cells' culture system that allows the in vitro recapitulation of organs/tissues structure complexity. Pluripotent and adult stem cells are included in a peculiar microenvironment consisting of a supporting structure (an extracellular matrix (ECM)-like component) and a cocktail of soluble bioactive molecules that, together, mimic the stem cell niche organization. It is noteworthy that the balance of all microenvironmental components is the most critical step for obtaining the successful development of an accurate organoid instead of an organoid with heterogeneous morphology, size, and cellular composition. Within this system, mechanical forces exerted on stem cells are collected by cellular proteins and transduced via mechanosensing-mechanotransduction mechanisms in biochemical signaling that dictate the stem cell specification process toward the formation of organoids. This review discusses the role of the environment in organoids formation and focuses on the effect of physical components on the developmental system. The work starts with a biological description of organoids and continues with the relevance of physical forces in the organoid environment formation. In this context, the methods used to generate organoids and some relevant published reports are discussed as examples showing the key role of mechanosensing-mechanotransduction mechanisms in stem cell-derived organoids.

Indexed as

CuesOrganoidsMechanotransduction, CellularStem CellsAdult stem cellsMechanosensingMechanotransductionPluripotent stem cellsStem cells specification

Identifiers

PMID34120215
PMCPMC8964551

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.