Evidence map›Paper›PMID 34120175›Full record

SynthesisAge and ageing2021

Efficacy of exercise-based interventions in preventing falls among community-dwelling older persons with cognitive impairment: is there enough evidence? An updated systematic review and meta-analysis.

Fuzhong Li, Peter Harmer, Elizabeth Eckstrom, Barbara E Ainsworth, Kathleen Fitzgerald, Jan Voit, Li-Shan Chou, Fei Li Welker, Shana Needham

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Age and ageing, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Guideline
  4. Trial
  5. Article
  6. Article
  7. Article
  8. What to Know About Falls in Older Adults? Risk Factors, Predictors, and Therapeutic Interventions.International journal of environmental research and public health · 2025
    Review
  9. Article
  10. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Review
  11. Move more, age well: prescribing physical activity for older adults.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
    Review
  12. Falls and Alzheimer Disease.Advances in geriatric medicine and research · 2024
    Article
  13. Article
  14. Italian guidance on Dementia Day Care Centres: A position paper.Aging clinical and experimental research · 2023
    Review
  15. Observational
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fuzhong LiOregon Research Institute, Eugene, OR 97403, USA.
Peter HarmerWillamette University, Department of Exercise and Health Science, Salem, OR 97301, USA.
Elizabeth EckstromDivision of General Internal Medicine & Geriatrics, Oregon Health & Science University, Portland, OR 97239, USA.
Barbara E AinsworthShanghai University of Sport, Shanghai, China.
Kathleen FitzgeraldMcKenzie Willamette Medical Center, Springfield, OR 97477, USA.
Jan VoitVoit Better Balance, Seattle, WA 98104, USA.
Li-Shan ChouIowa State University, Department of Kinesiology, Ames, IA 50011, USA.
Fei Li WelkerOregon Research Institute, Eugene, OR 97403, USA.
Shana NeedhamOregon Research Institute, Eugene, OR 97403, USA.

Funding

Efficacy of Adapted Tai Ji Quan to Slow Cognitive Decline in Older AdultsR01AG059546 · NIA · OREGON RESEARCH INSTITUTE · PI LI, FUZHONG · 2019 to 2023
$4.3M
Developing an Efficacious and Cost-Effective Fall Prevention ProgramR01AG045094 · NIA · OREGON RESEARCH INSTITUTE · PI LI, FUZHONG · 2014 to 2019
$3.2M
NIA NIH HHS AG059546NIA NIH HHS R01 AG045094NIA NIH HHS R01 AG059546
6 · The paper itself

Abstract

objectiveExercise prevents falls in the general older population, but evidence is inconclusive for older adults living with cognitive impairment. We performed an updated systematic review and meta-analysis to assess the potential effectiveness of interventions for reducing falls in older persons with cognitive impairment.

methodsPubMed, EMBASE, CINAHL, Scopus, CENTRAL and PEDro were searched from inception to 10 November 2020. We included randomised controlled trials (RCTs) that evaluated the effects of physical training compared to a control condition (usual care, waitlist, education, placebo control) on reducing falls among community-dwelling older adults with cognitive impairment (i.e. any stage of Alzheimer's disease and related dementias, mild cognitive impairment).

resultsWe identified and meta-analysed nine studies, published between 2013 and 2020, that included 12 comparisons (N = 1,411; mean age = 78 years; 56% women). Overall, in comparison to control, interventions produced a statistically significant reduction of approximately 30% in the rate of falls (incidence rate ratio = 0.70; 95% CI, 0.52-0.95). There was significant between-trial heterogeneity (I2 = 74%), with most trials (n = 6 studies [eight comparisons]) showing no reductions on fall rates. Subgroup analyses showed no differences in the fall rates by trial-level characteristics. Exercise-based interventions had no impact on reducing the number of fallers (relative risk = 1.01; 95% CI, 0.90-1.14). Concerns about risk of bias in these RCTs were noted, and the quality of evidence was rated as low.

conclusionsThe positive statistical findings on reducing fall rate in this meta-analysis were driven by a few studies. Therefore, current evidence is insufficient to inform evidence-based recommendations or treatment decisions for clinical practice.PROSPERO Registration number: CRD42020202094.

Indexed as

Cognitive DysfunctionIndependent LivingAgedAged, 80 and overBiasExerciseFemaleHumansMalecognitive functionexercise trainingfall preventionincidental fallsolder peoplesystematic review

Identifiers

PMID34120175
PMCPMC8437077

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.