Evidence map›Paper›PMID 34119852›Full record

ArticleInternational journal of hygiene and environmental health2021

Characterizing exposures to flame retardants, dioxins, and furans among firefighters responding to controlled residential fires.

Alexander C Mayer, Kenneth W Fent, I-Chen Chen, Deborah Sammons, Christine Toennis, Shirley Robertson, Steve Kerber, Gavin P Horn, Denise L Smith, Antonia M Calafat and 2 more

Open access · hybridAbstract read
In one paragraph

Article in International journal of hygiene and environmental health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  8. Review
  9. Article
  10. Article
  11. The MAK collection for occupational health and safety · 2024
    Article
  12. Article
  13. Article
  14. Mental health of UK firefighters.Scientific reports · 2023
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Alexander C MayerDivision of Field Studies and Engineering, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Cincinnati, OH, USA. Electronic address: Nru1@cdc.gov.
Kenneth W FentDivision of Field Studies and Engineering, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Cincinnati, OH, USA.
I-Chen ChenDivision of Field Studies and Engineering, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Cincinnati, OH, USA.
Deborah SammonsHealth Effects Laboratory Division, NIOSH, CDC, Cincinnati, OH, USA.
Christine ToennisHealth Effects Laboratory Division, NIOSH, CDC, Cincinnati, OH, USA.
Shirley RobertsonHealth Effects Laboratory Division, NIOSH, CDC, Cincinnati, OH, USA.
Steve KerberFirefighter Safety Research Institute, Underwriters Laboratories, Columbia, MD, USA.
Gavin P HornFirefighter Safety Research Institute, Underwriters Laboratories, Columbia, MD, USA; Illinois Fire Service Institute, University of Illinois at Urbana-Champaign, IL, USA.
Denise L SmithSkidmore College, Saratoga Springs, NY, USA; Illinois Fire Service Institute, University of Illinois at Urbana-Champaign, IL, USA.
Antonia M CalafatDivision of Laboratory Services, National Center for Environmental Health, CDC, Atlanta, GA, USA.
Maria OspinaDivision of Laboratory Services, National Center for Environmental Health, CDC, Atlanta, GA, USA.
Andreas SjodinDivision of Laboratory Services, National Center for Environmental Health, CDC, Atlanta, GA, USA.
Centers for Disease Control and Prevention · USNational Center for Environmental Health · USNational Institute for Occupational Safety and Health · USUniversity of Illinois Urbana-Champaign · USUL Research Institutes · US

Funding

Reconstructed Skin Micronucleus Genotoxicity AssayR44ES015002 · NIEHS · MATTEK CORPORATION · PI KALUZHNY, YULIA · 2009 to 2010
$819k
Pre-validation of Tissue Specific Micronucleus Assay for Genotoxicity TestingR43ES015002 · NIEHS · MATTEK CORPORATION · PI KALUZHNY, YULIA · 2006 to 2006
$208k
Intramural CDC HHS CC999999NIEHS NIH HHS R43 ES015002NIEHS NIH HHS R44 ES015002
6 · The paper itself

Abstract

Firefighters may encounter items containing flame retardants (FRs), including organophosphate flame retardants (OPFRs) and polybrominated diphenyl ethers (PBDEs), during structure fires. This study utilized biological monitoring to characterize FR exposures in 36 firefighters assigned to interior, exterior, and overhaul job assignments, before and after responding to controlled residential fire scenarios. Firefighters provided four urine samples (pre-fire and 3-h, 6-h, and 12-h post-fire) and two serum samples (pre-fire and approximately 23-h post-fire). Urine samples were analyzed for OPFR metabolites, while serum samples were analyzed for PBDEs, brominated and chlorinated furans, and chlorinated dioxins. Urinary concentrations of diphenyl phosphate (DPhP), a metabolite of triphenyl phosphate (TPhP), bis(1,3-dichloro-2-propyl) phosphate (BDCPP), a metabolite of tris(1,3-dichloro-2-propyl) phosphate (TDCPP), and bis(2-chloroethyl) phosphate (BCEtP), a metabolite of tris(2-chloroethyl) phosphate (TCEP), increased from pre-fire to 3-hr and 6-hr post-fire collection, but only the DPhP increase was statistically significant at a 0.05 level. The 3-hr and 6-hr post-fire concentrations of DPhP and BDCPP, as well as the pre-fire concentration of BDCPP, were statistically significantly higher than general population levels. BDCPP pre-fire concentrations were statistically significantly higher in firefighters who previously participated in a scenario (within the past 12 days) than those who were responding to their first scenario as part of the study. Similarly, firefighters previously assigned to interior job assignments had higher pre-fire concentrations of BDCPP than those previously assigned to exterior job assignments. Pre-fire serum concentrations of 2,3,4,7,8-pentachlorodibenzofuran (23478-PeCDF), a known human carcinogen, were also statistically significantly above the general population levels. Of the PBDEs quantified, only decabromodiphenyl ether (BDE-209) pre- and post-fire serum concentrations were statistically significantly higher than the general population. These results suggest firefighters absorbed certain FRs while responding to fire scenarios.

Indexed as

DioxinsFirefightersFiresFlame RetardantsFuransHalogenated Diphenyl EthersHumansOrganophosphatesDioxinsFlame RetardantsFuransHalogenated Diphenyl EthersOrganophosphatesBiomonitoringFirefightersFuransOccupational exposureOrganophosphate flame retardants (OPFRs)Polybrominated diphenyl ethers (PBDEs)

Identifiers

PMID34119852
PMCPMC8325627
OpenAlexW3172586912

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.