Evidence map›Paper›PMID 34119654›Full record

ArticleComparative biochemistry and physiology. Toxicology & pharmacology : CBP2021

Bisphenol A affects the pulse rate of Lumbriculus variegatus via an estrogenic mechanism.

Yuyang Wang, Hong-Sheng Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yuyang WangHefei No. 8 High School, Hefei, Anhui, China.
Hong-Sheng WangDepartment of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: wanghs@uc.edu.
University of Cincinnati Medical Center · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI YADAV, JAGJIT S · 1992 to 2022
$35.4M
Endocrine Disruptors and Heart HealthR01ES027855 · NIEHS · UNIVERSITY OF CINCINNATI · PI RUBINSTEIN, JACK, WANG, HONG-SHENG · 2018 to 2022
$2.1M
NIEHS NIH HHS P30 ES006096NIEHS NIH HHS R01 ES027855
6 · The paper itself

Abstract

Invertebrates are recognized as important species in endocrine disrupting chemical (EDC) testing. However, it is poorly understood whether the effects of EDCs in invertebrates are mediated by hormonal mechanisms. Previously, we showed that bisphenol A (BPA) affected the physiology of the freshwater oligochaete Lumbriculus variegatus. In the present study, we examined the mechanism of the impact of BPA on L. variegatus, using pulse rate of the dorsal blood vessel (DBV) as an endpoint. Both long term and acute exposures to BPA increased the pulsing rate of DBV. The former had a distinct inverted-U dose response relationship with a most efficacious dose of 10

Indexed as

AnimalsBenzhydryl CompoundsBisphenol A CompoundsEndocrine DisruptorsEstrogens, Non-SteroidalOligochaetaPhenolsWater Pollutants, ChemicalBenzhydryl Compoundsbisphenol ABisphenol A CompoundsEndocrine DisruptorsEstrogens, Non-SteroidalPhenolsWater Pollutants, ChemicalBPAEndocrine disruptorEstrogenInvertebrateLumbriculus variegatusMechanism

Identifiers

PMID34119654
PMCPMC8373826
OpenAlexW3172626981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.