Evidence map›Paper›PMID 34119639›Full record

ReviewNeuroImage2021

Partial volume correction analysis for

Yihuan Lu, Takuya Toyonaga, Mika Naganawa, Jean-Dominique Gallezot, Ming-Kai Chen, Adam P Mecca, Christopher H van Dyck, Richard E Carson

Abstract readReview
In one paragraph

Review in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Stage-dependent tau-PET signatures in Huntington's disease revealed by [¹⁸F]PI-2620.European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
  4. Review
  5. Synaptic density imaging in behavioral variant frontotemporal dementia: A comparison ofAlzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  6. Observational
  7. Review
  8. Article
  9. Article
  10. Molecular psychiatry · 2025
    Article
  11. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  12. Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  13. An In Vivo High-Resolution Human Brain Atlas of Synaptic Density.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  14. The associations between synaptic density and "A/T/N" biomarkers in Alzheimer's disease: AnJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Test-retest performance of [Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  19. Article
  20. In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yihuan LuDepartment of Radiology and Biomedical Imaging, Yale University, PO Box 208048, New Haven, CT 06520-8048, United States. Electronic address: Yihuan.lu@yale.edu.
Takuya ToyonagaDepartment of Radiology and Biomedical Imaging, Yale University, PO Box 208048, New Haven, CT 06520-8048, United States.
Mika NaganawaDepartment of Radiology and Biomedical Imaging, Yale University, PO Box 208048, New Haven, CT 06520-8048, United States.
Jean-Dominique GallezotDepartment of Radiology and Biomedical Imaging, Yale University, PO Box 208048, New Haven, CT 06520-8048, United States.
Ming-Kai ChenDepartment of Radiology and Biomedical Imaging, Yale University, PO Box 208048, New Haven, CT 06520-8048, United States.
Adam P MeccaDepartment of Psychiatry, Yale University, New Haven, CT, United States.
Christopher H van DyckDepartment of Psychiatry, Yale University, New Haven, CT, United States.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale University, PO Box 208048, New Haven, CT 06520-8048, United States.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARANDA, MARIA P. · 1985 to 2019
$41.0M
Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
The Aging Brain: Vasculature, Ischemia, and BehaviorP01AG012435 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WEINER, MICHAEL W · 1994 to 2012
$26.4M
Yale Alzheimer Disease Research CenterP50AG047270 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2015 to 2019
$8.3M
PET Imaging of SV2A and Other Biomarkers in Alzheimer's DiseaseR01AG062276 · NIA · YALE UNIVERSITY · PI VAN DYCK, CHRISTOPHER H · 2018 to 2022
$5.5M
PET Imaging of Synaptic Density in Alzheimers DiseaseR01AG052560 · NIA · YALE UNIVERSITY · PI CARSON, RICHARD E., VAN DYCK, CHRISTOPHER H · 2017 to 2020
$3.2M
Investigation of molecular changes in mGluR5 and SV2A to study synaptic alterations in Alzheimer's disease using PET.K23AG057794 · NIA · YALE UNIVERSITY · PI MECCA, ADAM PETER · 2018 to 2022
$977k
NCATS NIH HHS UL1 TR000142NCATS NIH HHS UL1 TR001863NIA NIH HHS K23 AG057794NIA NIH HHS P01 AG012435NIA NIH HHS P30 AG066508NIA NIH HHS P30 AG066530NIA NIH HHS P50 AG005142NIA NIH HHS P50 AG047270NIA NIH HHS R01 AG052560NIA NIH HHS R01 AG062276
6 · The paper itself

Abstract

purpose

methodsWe performed two PVC algorithms, Müller-Gärtner (MG) and 'iterative Yang' (IY), on 17 AD participants and 11 cognitive normal (CN) participants using the brain-dedicated HRRT scanner. Distribution volume V

resultsIn most regions, both PVC algorithms reduced the between-group differences. Alternatively, in hippocampus, IY increased the significance of between-group differences while MG reduced it (V

conclusion

Indexed as

Alzheimer DiseaseBrainCerebrovascular CirculationHumansImage Processing, Computer-AssistedPositron-Emission TomographyRadiopharmaceuticalsRadiopharmaceuticals

Identifiers

PMID34119639
PMCPMC8454285

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.