ArticleNeuroImage2021
Measuring the iron content of dopaminergic neurons in substantia nigra with MRI relaxometry.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 3 citations in OpenAlex.
- ASCANIO: a backscattering X-ray multichannel spectrometer for synchrotron applications.Journal of synchrotron radiation · 2026Article
- A neuroimaging atlas of the nigrosomes in the substantia nigra based on 3D histology.Scientific data · 2026Article
- 7 Tesla MRI with Quantitative Susceptibility Mapping: qualitative grading and quantitative focal measurements of the substantia nigra as a potential biomarker for Parkinson's disease.Neuroradiology · 2026Article
- Mapping the Silent Onset of Parkinson's Disease: Monoamine Imaging in the Era of the Race for Preclinical Intervention.Current neurology and neuroscience reports · 2026Review
- Ferritin in ferroptosis: Implications for neurodegenerative diseases (Review).International journal of molecular medicine · 2026Review
- Associations between iron and mean kurtosis in iron-rich grey matter nuclei in aging.Magma (New York, N.Y.) · 2026Article
- Axonal microstructure and compartmentalization impact the orientation and time dependence of mesoscopic transverse relaxation.Scientific reports · 2026Article
- The role of brain MR and FDG-PET in the diagnosis of neurodegenerative disease.European radiology · 2026Review
- Neuroimaging and Pathology Biomarkers in Parkinson's Disease and Parkinsonism.Brain sciences · 2026Article
- Response to: Neuromelanin?Brain communications · 2026Article
- Integrated evaluation of Nigrosome 1 sign, neuromelanin-sensitive MR and iron deposition.Japanese journal of radiology · 2026Article
- Sodium Para-Aminosalicylic Acid Inhibits Manganese-Iron Co-exposure-induced Inflammation via the NF-κB Pathway in Rat Substantia Nigra.Neurochemical research · 2025Article
- Modeling Midbrain and Brainstem Neuromelanins to Characterize Metal Binding and Associated MRI Contrast in Parkinson's and Alzheimer's Diseases.Angewandte Chemie (International ed. in English) · 2025Article
- Reduced Brain Iron and Striatal Hyperdopaminergia in Schizophrenia: A Quantitative Susceptibility Mapping MRI and PET Study.The American journal of psychiatry · 2025Article
- Unraveling the major role of vascular (R2') contributions to R2* signal relaxation at ultra-high-field MRI: A comprehensive analysis with quantitative gradient recalled echo in mouse brain.Magnetic resonance in medicine · 2025Article
- In Vivo Characterization of Magnetic Inclusions in the Subcortex From Nonexponential Transverse Relaxation Decay.NMR in biomedicine · 2025Article
- Multimodal magnetic resonance imaging studies on non-motor symptoms of Parkinson's disease.IBRO neuroscience reports · 2025Article
- High-resolution mapping of substantia nigra in Parkinson's disease using 7 tesla magnetic resonance imaging.NPJ Parkinson's disease · 2025Article
- High correlation of quantitative susceptibility mapping and echo intensity measurements of nigral iron overload in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Predicting Mesoscopic Larmor Frequency Shifts in White Matter With Diffusion MRI-A Monte Carlo Study in Axonal Phantoms.NMR in biomedicine · 2025Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Parkinson's disease, the depletion of iron-rich dopaminergic neurons in nigrosome 1 of the substantia nigra precedes motor symptoms by two decades. Methods capable of monitoring this neuronal depletion, at an early disease stage, are needed for early diagnosis and treatment monitoring. Magnetic resonance imaging (MRI) is particularly suitable for this task due to its sensitivity to tissue microstructure and in particular, to iron. However, the exact mechanisms of MRI contrast in the substantia nigra are not well understood, hindering the development of powerful biomarkers. In the present report, we illuminate the contrast mechanisms in gradient and spin echo MR images in human nigrosome 1 by combining quantitative 3D iron histology and biophysical modeling with quantitative MRI on post mortem human brain tissue. We show that the dominant contribution to the effective transverse relaxation rate (R
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.