Evidence map›Paper›PMID 34119538›Full record

ArticleLife sciences2021

Predicting post-exertional malaise in Gulf War Illness based on acute exercise responses.

Alexander E Boruch, Jacob B Lindheimer, Jacquelyn C Klein-Adams, Aaron J Stegner, Glenn R Wylie, Jacob V Ninneman, Thomas Alexander, Nicholas P Gretzon, Bishoy Samy, Stephanie M Van Riper and 2 more

Open access · greenAbstract read
In one paragraph

Article in Life sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Alexander E BoruchWilliam S. Middleton Memorial Veterans Hospital, Madison, WI, United States of America; Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States of America.
Jacob B LindheimerWilliam S. Middleton Memorial Veterans Hospital, Madison, WI, United States of America; Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States of America; Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States of America.
Jacquelyn C Klein-AdamsWar Related Illness and Injury Study Center, Department of Veterans Affairs New Jersey Health Care System, East Orange, NJ, United States of America.
Aaron J StegnerWilliam S. Middleton Memorial Veterans Hospital, Madison, WI, United States of America; Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States of America.
Glenn R WylieWar Related Illness and Injury Study Center, Department of Veterans Affairs New Jersey Health Care System, East Orange, NJ, United States of America; Kessler Foundation, The Rocco Ortenzio Neuroimaging Center, West Orange, NJ, United States of America; Department of Pharmacology, Physiology, and Neuroscience, Rutgers, New Jersey Medical School, Newark, New Jersey, United States of America; Department of Physical Medicine and Rehabilitation, Rutgers, New Jersey Medical School, Newark, New Jersey, United States of America.
Jacob V NinnemanWilliam S. Middleton Memorial Veterans Hospital, Madison, WI, United States of America; Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States of America.
Thomas AlexanderWar Related Illness and Injury Study Center, Department of Veterans Affairs New Jersey Health Care System, East Orange, NJ, United States of America.
Nicholas P GretzonWilliam S. Middleton Memorial Veterans Hospital, Madison, WI, United States of America; Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States of America.
Bishoy SamyWar Related Illness and Injury Study Center, Department of Veterans Affairs New Jersey Health Care System, East Orange, NJ, United States of America.
Stephanie M Van RiperWilliam S. Middleton Memorial Veterans Hospital, Madison, WI, United States of America; Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States of America.
Michael J FalvoWar Related Illness and Injury Study Center, Department of Veterans Affairs New Jersey Health Care System, East Orange, NJ, United States of America; Department of Pharmacology, Physiology, and Neuroscience, Rutgers, New Jersey Medical School, Newark, New Jersey, United States of America; Department of Physical Medicine and Rehabilitation, Rutgers, New Jersey Medical School, Newark, New Jersey, United States of America.
Dane B CookWilliam S. Middleton Memorial Veterans Hospital, Madison, WI, United States of America; Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States of America. Electronic address: dane.cook@wisc.edu.
VA New Jersey Health Care System · USWilliam S. Middleton Memorial Veterans Hospital · USUniversity of Wisconsin–Madison · USRutgers New Jersey Medical School

Funding

Post exertion malaise in GWI_Brain autonomic and behavioral interactionsI01CX001329 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI DANE B. COOK, Michael J. Falvo · 2016 to 2026
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Acute exercise tolerance among Veterans with Gulf War IllnessIK2CX001679 · VA · WM S. MIDDLETON MEMORIAL VETERANS HOSP · PI LINDHEIMER, JACOB · 2018 to 2023
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CSRD VA I01 CX001329CSRD VA IK2 CX001679CSRD VA IK6 CX002369
6 · The paper itself

Abstract

aimsPost-exertional malaise (PEM) is poorly understood in Gulf War Illness (GWI). Exercise challenges have emerged as stimuli to study PEM; however, little attention has been paid to unique cardiorespiratory and perceptual responses during exercise. This study tested whether select exercise parameters explained variability in PEM responses. MAIN

methodsVisual analog scale (0-100) versions of the Kansas questionnaire were used for daily symptom measurements one week before and one week after 30-min of cycling at 70% heart rate reserve in 43 Veterans with GWI and 31 Veteran controls (CON). Cardiopulmonary exercise testing (CPET) methods were used to measure oxygen (VO KEY

findingsCompared to CON, Veterans with GWI had greater ventilatory equivalent for oxygen (VE/VO SIGNIFICANCE: The PEM response was not related to the selected combination of cardiorespiratory and perceptual responses to exercise.

Indexed as

ExerciseAgedExercise TestFatigueFemaleHeart RateHumansMaleMiddle AgedMyalgiaPersian Gulf SyndromeCardiopulmonaryChronicExercise testsFatigueFatigue syndromePainPersian Gulf War

Identifiers

PMID34119538
PMCPMC10214407
OpenAlexW3167271414

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.