SynthesisGastroenterology2021
Early-Age Onset Colorectal Neoplasia in Average-Risk Individuals Undergoing Screening Colonoscopy: A Systematic Review and Meta-Analysis.
Synthesis in Gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023Guideline
- Gut Microbial Topology and Metabolic Signatures Associated With Colorectal Neoplasia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Closing the Diagnostic Gap in Early-Onset Colorectal Cancer: Red-Flag Symptoms, Screening, and Inherited Risk.Cancers · 2026Review
- Age Inflection Points of Colorectal Adenoma Risk in Young Adults: A Joinpoint Regression Analysis of a Single-Center Retrospective Colonoscopy-Based Cohort.Journal of clinical medicine · 2026Article
- Shifting paradigms in 30,427 surgical colorectal cancer cases (2008-2023): the impact of endoscopic screening on caseload complexity and the value of minimally invasive quality.Surgical endoscopy · 2026Article
- Clinicopathological Features of Endoscopically Resected Early-Onset Colorectal Neoplasia Compared with Later-Onset Cases.Cancers · 2026Article
- Knowledge, attitudes, and intended practices regarding colorectal polyps among patients: a cross-sectional study.Frontiers in oncology · 2026Article
- Microbiota disparities in stool, oral swabs, and saliva between control and early-onset colorectal neoplasia groups: an exploratory analysis.Frontiers in microbiomes · 2026Article
- Observational
- Risk of Advanced Adenomas in Siblings Aged ≤ 50 Years of Patients with Early-Onset Colorectal Advanced Adenomas.Digestive diseases and sciences · 2025Article
- Colorectal Neoplasia in Vietnamese Patients Under 50 Years of Age: A Cross-Sectional Study.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025Article
- A Score to Predict Advanced Colorectal Neoplasia in Adults Younger than Age 45.Digestive diseases and sciences · 2025Article
- Early Detection and Age-Comparative Analysis of Colorectal Cancer Screening: Insights from the Turkish Population.Current oncology (Toronto, Ont.) · 2025Article
- PET-Assessed Metabolic Tumor Volume Across the Spectrum of Solid-Organ Malignancies: A Review of the Literature.Biomedicines · 2025Review
- Random forests algorithm using basic medical data for predicting the presence of colonic polyps.Frontiers in surgery · 2025Article
- Association between Diverticulosis and Colorectal Neoplasia: Analysis from a Large Austrian Database.Journal of clinical medicine · 2024Article
- Article
- Association ofCurrent issues in molecular biology · 2024Article
- Esophagogastroscopic Abnormalities Potentially Guided Patients Younger than 50 Years Old to Undergo Colonoscopy Earlier: A Retrospective Cross-Sectional Study.Digestive diseases and sciences · 2024Article
- Global burden of early-onset colorectal cancer among people aged 40-49 years from 1990 to 2019 and predictions to 2030.Journal of cancer research and clinical oncology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsIncidence and mortality associated with early-age onset colorectal cancer (EAO-CRC) is increasing, prompting professional society recommendations to lower the screening age in average-risk individuals. The yield of screening individuals younger than 50 years is not known.
methodsA systematic review of 3 databases from inception through July 2020 was performed in all languages that reported colonoscopy findings in average-risk individuals younger than 50 years. The primary outcomes were EAO colorectal neoplasia (CRN) and advanced colorectal neoplasia (aCRN) prevalence. Subgroup analyses were performed based on sex, geographic location, time period, and age, including comparison with those aged 50-59 years. Generalized linear mixed model with random intercept logistic regression and fixed subgroup effects were performed.
resultsOf 10,123 unique articles, 17 studies published between 2002 and 2020, including 51,811 average-risk individuals from 4 continents, were included. The pooled rate of EAO-CRN was 13.7% (95% confidence interval [CI], 0.112%-0.168%) and EAO-aCRN was 2.2% (95% CI, 0.016%-0.031%). Prevalence of CRC was 0.05% (95% CI, 0.00029%-0.0008%). Rates of EAO-CRN were higher in men compared with women (relative risk, 1.71%; 95% CI, 1.49%-1.98%), and highest in the United States (15.6%; 95% CI, 12.2%-19.7%) compared with Europe (14.9%; 95% CI, 6.9%-29.3%), East Asia (13.4%; 95% CI, 10.3%-17.2%), and the Middle East (9.8%; 95% CI, 7.8%-12.2%) (P = .04) The rate of EAO-CRN in age groups 45-49 years and 50-59 years was 17.8% (95% CI, 14.5%-21.6%) and 24.8% (95% CI, 19.5%-30.8%), respectively (P = .04). The rate of EAO-aCRN in age group 45-49 years was 3.6% (95% CI, 1.9%-6.7%) and 4.2% (95% CI, 3.2%-5.7%), respectively (P = .69).
conclusionsThe rate of aCRN in individuals aged 45-49 years was similar to the rate observed in individual aged 50-59 years, suggesting that expanding screening to this population could yield a similar impact on colorectal cancer risk reduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.