ArticleThe American journal of pathology2021
Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice.
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Article in The American journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Mesothelin/Mucin 16 Signaling in Activated Portal Fibroblasts Drives the Development of Cholestatic Fibrosis and Hepatocellular Carcinoma in Aged Female Multidrug Resistance Protein 2 Knockout Mice.Cellular and molecular gastroenterology and hepatology · 2026Article
- DHCR7 inhibition ameliorates MetALD and HCC in mice and human 3D liver spheroids.JHEP reports : innovation in hepatology · 2025Article
- Platelet C3G protects from liver fibrosis, while enhancing tumor growth through regulation of the immune response.The Journal of pathology · 2025Article
- Hepatic Stellate Cells Functional Heterogeneity in Liver Cancer.Seminars in liver disease · 2025Review
- Activation of the Wnt signaling pathway and its role in epithelial-mesenchymal transition and hepatic fibrosis in alveolar echinococcosis.Frontiers in cellular and infection microbiology · 2025Article
- The Spatial Extracellular Proteomic Tumor Microenvironment Distinguishes Molecular Subtypes of Hepatocellular Carcinoma.Journal of proteome research · 2024Article
- Fibroblasts in liver cancer: functions and therapeutic translation.The lancet. Gastroenterology & hepatology · 2023Review
- Cancer cell survival depends on collagen uptake into tumor-associated stroma.Nature communications · 2022Article
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- Toxicity study in a pig model of intraperitoneal collagenase as an "enzymatic scalpel" directed to break stroma in order to generate a new perspective for peritoneal carcinomatosis approach: an experimental research.World journal of surgical oncology · 2022Article
- Immune Modulatory Properties of Collagen in Cancer.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Jacopo BaglieriDepartment of Medicine, University of California San Diego, San Diego, California; Department of Surgery, University of California San Diego, San Diego, California.
Cuili ZhangDepartment of Medicine, University of California San Diego, San Diego, California.
Shuang LiangDepartment of Medicine, University of California San Diego, San Diego, California.
Xiao LiuDepartment of Medicine, University of California San Diego, San Diego, California.
Takahiro NishioDepartment of Medicine, University of California San Diego, San Diego, California.
Sara B RosenthalCenter for Computational Biology and Bioinformatics, University of California San Diego, San Diego, California.
Debanjan DharDepartment of Medicine, University of California San Diego, San Diego, California.
Hua SuDepartment of Pharmacology, University of California San Diego, San Diego, California.
Min CongLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Disease, Beijing, China.
Jidong JiaLiver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Translational Medicine in Liver Cirrhosis and National Clinical Research Center of Digestive Disease, Beijing, China.
Mojgan HosseiniDepartment of Pathology, University of California San Diego, San Diego, California.
Michael KarinDepartment of Pharmacology, University of California San Diego, San Diego, California.
Tatiana KisselevaDepartment of Surgery, University of California San Diego, San Diego, California.
David A BrennerDepartment of Medicine, University of California San Diego, San Diego, California. Electronic address: dbrenner@health.ucsd.edu.
University of California San Diego · USCapital Medical University · CNUC San Diego Health System · USUniversity of San Diego · US
Funding
The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ANNA S. GUKOVSKAYA · 1999 to 2026
$45.8MUC San Diego Clinical and Translational Research InstituteKL2TR001444 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DEPP, COLIN A. · 2015 to 2024
$15.4MREGULATION OF NFKB AND IKK BY PROINFLAMMATORY STIMULIR01AI043477 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARIN, MICHAEL · 1998 to 2017
$7.4MNF-kappaB and Mitochondrial Signals as Positive and Negative Regulators of InflammationR37AI043477 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael Karin · 2018 to 2026
$6.0MInactivation of Hepatic Stellate Cells During Reversal of Liver FibrosisR01DK099205 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRENNER, DAVID A., KISSELEVA, TATIANA · 2014 to 2025
$4.8MThe Role of Portal Fibroblasts in Cholestatic Liver FibrosisR01DK101737 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KISSELEVA, TATIANA · 2014 to 2025
$3.8MNovel IL-23 inhibitor for the treatment of alcohol associated liver diseaseU01AA029019 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KISSELEVA, TATIANA, LOOMBA, ROHIT · 2020 to 2024
$3.7MEpigenetic Regulation of Alcoholic Liver FibrosisU01AA018663 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KISSELEVA, TATIANA, MANN, DEREK · 2010 to 2019
$3.7MThe role of IL-17 signaling in alcohol-induced HCCR01AA028550 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRENNER, DAVID A., KISSELEVA, TATIANA · 2021 to 2025
$2.3MThe Role of IL-17 in Alcoholic Liver Disease and CancerU01AA022614 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KARIN, MICHAEL, KISSELEVA, TATIANA · 2014 to 2018
$1.8MFibrocytes regulate liver fibrosisR01DK111866 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KISSELEVA, TATIANA · 2017 to 2020
$1.4MTNF AND NFKB AND EMBRYONIC LIVER DEVELOPMENTF32DK009920 · NIDDK · UNIVERSITY OF WASHINGTON · PI ROSENFELD, MARYLAND E · 1998 to 2001
$47kNCATS NIH HHS KL2 TR001444NIAAA NIH HHS P50 AA011999NIAAA NIH HHS R01 AA028550NIAAA NIH HHS U01 AA018663NIAAA NIH HHS U01 AA022614NIAAA NIH HHS U01 AA029019NIAID NIH HHS R01 AI043477NIAID NIH HHS R37 AI043477NIDDK NIH HHS F32 DK009920NIDDK NIH HHS R01 DK099205NIDDK NIH HHS R01 DK101737NIDDK NIH HHS R01 DK111866
Abstract
Although hepatocellular cancer (HCC) usually occurs in the setting of liver fibrosis, the causal relationship between liver fibrosis and HCC is unclear. in vivo and in vitro models of HCC involving Col
Indexed as
AnimalsCarcinoma, HepatocellularCell Line, TumorCollagen Type IHepatic Stellate CellsHumansLiver CirrhosisLiver Neoplasms, ExperimentalMiceMice, Inbred C57BLCollagen Type I
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.