Evidence map›Paper›PMID 34119468›Full record

ArticleJACC. Heart failure2021

Physical Activity, Subclinical Myocardial Injury, and Risk of Heart Failure Subtypes in Black Adults.

Kershaw V Patel, Shawn Simek, Colby Ayers, Ian J Neeland, Christopher deFilippi, Stephen L Seliger, Katy Lonergan, Nicole Minniefield, Robert J Mentz, Adolfo Correa and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 1 country.

Kershaw V PatelDepartment of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas, USA.
Shawn SimekDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Colby AyersDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ian J NeelandDivision of Cardiology, Department of Medicine, University Hospitals Harrington Heart and Vascular Institute and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Christopher deFilippiInova Heart and Vascular Institute, Falls Church, Virginia, USA.
Stephen L SeligerDepartment of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Katy LonerganDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Nicole MinniefieldDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Robert J MentzDivision of Cardiology, Duke Clinical Research Institute, Durham, North Carolina, USA.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Wondwosen K YimerDepartment of Data Science, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Michael E HallDepartment of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Carlos J RodriguezDivision of Cardiology, Department of Internal Medicine, Albert Einstein College of Medicine, Bronx, New York, USA.
James A de LemosDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Jarett D BerryDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ambarish PandeyDivision of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address: ambarish.pandey@utsouthwestern.edu.
The University of Texas Southwestern Medical Center · USUniversity of Mississippi Medical Center · USAlaska Heart and Vascular Institute · USAlbert Einstein College of Medicine · USClinical Research Institute · USHouston Methodist · USJackson Memorial Hospital · USSouthwestern Medical Center · USUniversity Hospitals of Cleveland · USUniversity of Maryland, Baltimore · US

Funding

The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve HealthUL1TR003015 · NCATS · UNIVERSITY OF VIRGINIA · PI BROWN, DONALD E, JOHNSTON, KAREN C. · 2019 to 2023
$20.3M
Epidemiologic Determinants of Change in Cardiac Structure and Function (ECHO-SOL 2)R01HL104199 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RODRIGUEZ, CARLOS JOSE · 2011 to 2018
$5.3M
Evaluation of Racial Differences in Cardiorespiratory Fitness Decline with Aging & Underlying Biological MechanismsR03AG067960 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI PANDEY, AMBARISH · 2020 to 2021
$327k
NCATS NIH HHS UL1 TR003015NHLBI NIH HHS R01 HL104199NIA NIH HHS R03 AG067960
6 · The paper itself

Abstract

objectivesThis study sought to evaluate the independent associations and interactions between high-sensitivity cardiac troponin I (hs-cTnI) and physical activity (PA) with risk of heart failure (HF) subtypes, HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF).

backgroundBlack adults are at high risk for developing HF. Physical inactivity and subclinical myocardial injury, as assessed by hs-cTnI concentration, are independent risk factors for HF.

methodsBlack adults from the Jackson Heart Study without prevalent HF who had hs-cTnI concentration and self-reported PA assessed at baseline were included. Adjusted Cox models were used to evaluate the independent and joint associations and interaction between hs-cTnI concentrations and PA with risk of HFpEF and HFrEF.

resultsAmong 3,959 participants, 25.1% had subclinical myocardial injury (hs-cTnI ≥4 and ≥6 ng/l in women and men, respectively), and 48.2% were inactive (moderate-to-vigorous PA = 0 min/week). Over 12.0 years of follow-up, 163 and 150 participants had an incident HFpEF and HFrEF event, respectively. In adjusted analysis, higher hs-cTnI concentration (per 1-U log increase) was associated with higher risk of HFpEF (hazard ratio [HR]: 1.47; 95% confidence interval [CI]: 1.25 to 1.72]) and HFrEF (HR: 1.57; 95% CI: 1.35 to 1.83]). In contrast, higher PA (per 1-U log increase) was associated with a lower risk of HFpEF (HR: 0.93; 95% CI: 0.88 to 0.99]) but not HFrEF. There was a significant interaction between hs-cTnI and PA for risk of HFpEF (p interaction = 0.04) such that inactive participants with subclinical myocardial injury were at higher risk of HFpEF but active participants were not.

conclusionsAmong Black adults with subclinical myocardial injury, higher levels of PA were associated with attenuated risk of HFpEF.

Indexed as

Heart FailureVentricular Dysfunction, LeftAdultExerciseFemaleHumansMalePrognosisRisk FactorsStroke VolumeTroponin ITroponin IBlack adultsheart failurephysical activitysubclinical myocardial injury

Identifiers

PMID34119468
PMCPMC10563362
OpenAlexW3167793733

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.