ReviewPoultry science2021
The physiological role of guanidinoacetic acid and its relationship with arginine in broiler chickens.
Review in Poultry science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- A meta-analysis of the effects and relationship between guanidinoacetic acid and the growth performance of broiler chickens.Poultry science · 2026Pooled it
- Guanidinoacetic acid enhances Tibetan sheep-meat quality through the gut-muscle axis: insights from metabolome-microbiome integration.Food chemistry. Molecular sciences · 2026Article
- Dietary guanidinoacetic acid supplementation favourably modulates energy dynamics and nitrogen balance in broilers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Integrated multi-omics analysis reveals breed-specific molecular and metabolic architectures of breast muscle in Cherry Valley, Muscovy, and mule ducks.Poultry science · 2026Article
- Interactive Effects of Dietary Guanidinoacetic Acid and Energy Density on Growth Performance, Carcass Characteristics, Meat Quality, and Heat Stress Tolerance in Broilers.Life (Basel, Switzerland) · 2026Article
- Dietary Guanidinoacetic Acid Improves Meat Tenderness and Antioxidant Capacity in Rabbits via Modulating Muscle Fiber Characteristics and Fat Metabolism.Animals : an open access journal from MDPI · 2026Article
- The Effects of Arginine, Guanidinoacetic Acid and Citrulline Supplementation to Reduced Protein Diets for Aged Laying Hens.Animals : an open access journal from MDPI · 2026Article
- Functional Amino Acid Supplementation Drives Early Growth and Gut Maturation in Broilers: A Meta-Analysis.Animals : an open access journal from MDPI · 2026Review
- Effects of Guanidinoacetic Acid and Metabolizable Energy Levels on Performance and Nutrient Metabolism in Broilers.Animals : an open access journal from MDPI · 2026Article
- The effect of rumen-protected methionine and guanidinoacetic acid on growth performance, hematological indices, and immune-related gene expression in suckling Holstein Calves.Veterinary and animal science · 2026Article
- The Beneficial Effects of Guanidinoacetic Acid as a Functional Feed Additive: A Possible Approach for Poultry Production.Veterinary sciences · 2026Review
- Effects on Rumen Microbial Population and Serum Biochemical Responses to Guanidinoacetic Acid,Animals : an open access journal from MDPI · 2025Article
- Dietary Guanidinoacetic Acid Supplementation Improves Growth Performance of Plateau Yaks Through Plasma Metabolome Modulation.Biology · 2025Article
- Integrated transcriptomic and phenotypic analysis reveals tissue-specific regulatory effects of guanidinoacetic acid in cattle.BMC genomics · 2025Article
- Effects of guanidinoacetic acid on gene expression in adipose tissue of broiler chickens: a differential expression analysis based on small RNA sequencing.Frontiers in veterinary science · 2025Article
- An Evaluation of the Arginine Requirements of Broiler Chickens and the Potential Arginine and Energy-Saving Effects of Guanidinoacetic Acid.Animals : an open access journal from MDPI · 2024Article
- Effects of Guanidine Acetic Acid on the Growth and Slaughter Performance, Meat Quality, Antioxidant Capacity, and Cecal Microbiota of Broiler Chickens.Veterinary sciences · 2024Article
- Association analysis of transcriptome and quasi-targeted metabolomics reveals the regulation mechanism underlying broiler muscle tissue development at different levels of dietary guanidinoacetic acid.Frontiers in veterinary science · 2024Article
- Guanidinoacetic Acid Attenuates Adipogenesis through Regulation of miR-133a in Sheep.Animals : an open access journal from MDPI · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of guanidinoacetic acid (GAA) and its relationship with arginine was reviewed in order to define a replacement ratio between GAA and arginine for broiler diet formulation, the ratio being of how much arginine could be spared, or replaced by GAA. Guanidionoacetic acid, the precursor of creatine, can be synthesized de novo from the amino acids arginine and glycine, whereby 1 mol of arginine creates 1 mol of GAA; that is a weight:weight (w:w) ratio of 1.49:1 (arginine:GAA). Guanidinoacetic acid exerts a growth effect through its primary physiological fate to form creatine, and additionally spares dietary arginine from GAA synthesis; so that it contributes to protein accretion and other functions. Creatine is critical in energy metabolism as a carrier and reservoir of phosphate for adenosine triphosphate (ATP) formation. Arginine deficiency causes reduced growth and can lead to disrupted levels of blood and muscle energy metabolites (phosphocreatine and creatine). Supplementing GAA into the diet restores these metabolites. At severe arginine deficiency, GAA addition cannot fully compensate the arginine deficit, as measured by growth performance. As arginine becomes nearer to sufficiency, the effect of GAA becomes more pronounced. When using growth rate or FCR as an indicator in broilers, a ratio in the range of 0.77 to 1.3:1 (w:w arginine:GAA) was seen, with one study noting a ratio of 2:1 when using FCR as an indicator. Higher ratios of up to 2.7:1 are achieved when using muscle creatine and phosphocreatine measurements. A recommendation of 1:1 (w:w) is proposed, which takes a conservative approach. Large scale studies with practical diets would be helpful to confirm that a ratio of 1:1 (w:w) or higher may be used in the field for broilers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.