ReviewSexual medicine2021
How Relevant is the Systemic Oxytocin Concentration for Human Sexual Behavior? A Systematic Review.
Review in Sexual medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Neural correlates of psychodynamic and non-psychodynamic therapies in different clinical populations through fMRI: A meta-analysis and systematic review.Frontiers in human neuroscience · 2022Pooled it
- Early life stress modulates social behavior via oxytocin and arginine vasopressin in males.European archives of psychiatry and clinical neuroscience · 2026Article
- Rethinking sexual pleasure in research, health care and society.Nature reviews. Urology · 2026Review
- Plant-derived bioactives in depression-related and antidepressant-associated sexual dysfunction: a narrative review.Frontiers in nutrition · 2026Review
- The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease.Endocrine reviews · 2025Review
- Impact of sexual activity on bulbocavernosus muscle stiffness assessed by shear wave elastography in women.Archives of gynecology and obstetrics · 2025Article
- Functional and Structural Alterations in Pediatric Multiple Sclerosis: A Systematic Review and a Preliminary Activation Likelihood Estimation Functional Magnetic Resonance Imaging Meta-Analysis.Pediatric reports · 2025Review
- Charting Salivary Oxytocin Across an Episode of Naturally Occurring Partnered Sex.Archives of sexual behavior · 2025Article
- How does oxytocin modulate human behavior?Molecular psychiatry · 2025Review
- Reduction of Prostate Cancer Risk: Role of Frequent Ejaculation-Associated Mechanisms.Cancers · 2025Review
- Salivary oxytocin and amygdalar alterations in functional neurological disorders.Brain communications · 2025Article
- Better sleep, lower blood pressure, and less stress following sex: Findings from a large-scale ecological momentary assessment study.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024Article
- Psychological symptoms and brain activity alterations in women with PCOS and their relation to the reduced quality of life: a narrative review.Journal of endocrinological investigation · 2024Review
- The Role of Oxytocin in Polycystic Ovary Syndrome: A Systematic Review.Current issues in molecular biology · 2024Review
- Exploring the Role of Masturbation as a Coping Strategy in Women.International journal of sexual health : official journal of the World Association for Sexual Health · 2024Article
- Can research on entactogens contribute to a deeper understanding of human sexuality?Pharmacological reports : PR · 2023Review
- Does activation of oxytocinergic reward circuits postpone the decline of the aging brain?Frontiers in psychology · 2023Review
- Deschloroclozapine exhibits an exquisite agonistic effect at lower concentration compared to clozapine-N-oxide in hM3Dq expressing chemogenetically modified rats.Frontiers in neuroscience · 2023Article
- The Relationship Between 5-Hydroxytryptamine and Its Metabolite Changes With Post-stroke Depression.Frontiers in psychiatry · 2022Review
- Missing pieces in decoding the brain oxytocin puzzle: Functional insights from mouse brain wiring diagrams.Frontiers in neuroscience · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDespite its role in social cognition and affiliative behavior, less is known about the role played by oxytocin in human sexual behavior.
aimIn the present systematic review, we aimed to find the levels of oxytocin related to human sexual arousal and orgasm.
methodsWe conducted the study according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. We performed a systematic search in the principal databases for studies that reported collection of salivary or plasmatic samples, with dosage of oxytocin in relation to sexual activity during induction of sexual arousal and orgasm.
results414 articles were obtained. After duplicates removal and the application of pre exclusion criteria, 16 articles were considered eligible and 13 articles were included with a Cohen's k of 0.827. Most of the studies used sexual self-stimulation and collected plasmatic or salivary samples to measure oxytocin. The sexual arousal and orgasm were assessed based on subjective reports.
main outcome measureThe primary outcomes were the oxytocin levels collected during the induction of sexual arousal and orgasm.
conclusionsSeveral studies collected only subjective reports about the sexual arousal and the orgasm. Most of the studies found higher levels of oxytocin during the orgasm or ejaculation. Given the sexual arousal evoked by self-stimulation in which sexual fantasies play an important role, it should be possible to postulate for a role of the oxytocin in sexual desire. In particular, we hypothesize a complex role of the oxytocin in the modulation of sexual fantasies and thoughts that are relevant in the sexual desire and help to trigger genital and sexual arousal. Cera N, Vargas-Cáceres S, Oliveira C, et al. How Relevant is the Systemic Oxytocin Concentration for Human Sexual Behavior? A Systematic Review. Sex Med 2021;9:100370.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.