Trial reportThe Journal of allergy and clinical immunology2022
Effect of vitamin D supplementation on total and allergen-specific IgE in children with asthma and low vitamin D levels.
Trial report in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Pooled it
- The Role of Vitamin D in Severity and Control of Asthma in Children and Adolescents: A Systematic Review and Meta-Analysis.Pediatric pulmonology · 2026Pooled it
- The effects of vitamin D supplementation on inflammatory biomarkers in patients with asthma: a systematic review and meta-analysis of randomized controlled trials.Frontiers in immunology · 2024Pooled it
- Vitamin D for the management of asthma.The Cochrane database of systematic reviews · 2023Pooled it
- Sun Exposure and Asthma Prevalence in Spanish Schoolchildren and Adolescents in the Global Asthma Network (GAN) Phase I Study: A Semi-Individual Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Importance of vitamin D in gastrointestinal health and disease.Frontiers in nutrition · 2026Review
- The therapeutic potential of vitamin D supplementation in asthma.Pharmacological reports : PR · 2025Review
- Prospective Study of Vitamin D Status and Risk of Developing Specific Immunoglobulin E During Mid-Childhood.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2024Article
- Environmental Interventions for Preventing Atopic Diseases.Current allergy and asthma reports · 2024Review
- The Association of Vitamin D Receptor Gene Polymorphisms with Vitamin D, Total IgE, and Blood Eosinophils in Patients with Atopy.Biomolecules · 2024Article
- Mini-Review on Vitamin D in Pediatric Population and its Role in Respiratory and Atopic Disorders.Mini reviews in medicinal chemistry · 2024Review
- Review
- Asthma and Vitamin D Deficiency: Occurrence, Immune Mechanisms, and New Perspectives.Journal of immunology research · 2022Review
- Association between 25-hydroxy vitamin D and lung function (FEV1, FVC, FEV1/FVC) in children and adults with asthma: A systematic review.Lung India : official organ of Indian Chest SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundObservational studies have yielded inconsistent findings for the relation between vitamin D level and total IgE or allergic sensitization.
objectiveTo determine whether vitamin D supplementation reduces levels of total IgE and IgE to each of 2 common indoor allergens in children with asthma and low vitamin D levels.
methodsTotal IgE, IgE to Dermatophagoides pteronyssinus, and IgE to Blattella germanica were measured at the randomization and exit visits for 174 participants in the Vitamin D Kids Asthma Study, a multicenter, double-blind, randomized placebo-controlled trial of vitamin D
resultsParticipants were followed for an average of 316 days. At the exit visit, more subjects in the vitamin D arm achieved a vitamin D level equal to or more than 30 ng/mL compared with those in the placebo arm (87% vs 30%; P < .001). In a multivariable analysis, vitamin D
conclusionsVitamin D supplementation, compared with placebo, has no significant effect on serum levels of total IgE, IgE to dust mite, or IgE to cockroach in children with asthma and low vitamin D levels.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.