Evidence map›Paper›PMID 34118214›Full record

ArticleBiochimica et biophysica acta. Biomembranes2021

Nonlinear material and ionic transport through membrane nanotubes.

D V Ivchenkov, P I Kuzmin, T R Galimzyanov, A V Shnyrova, P V Bashkirov, V A Frolov

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Biomembranes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

D V IvchenkovFederal Research and Clinical Center of Physical-Chemical Medicine, Moscow 119435, Russia; Department of Molecular and Biological Physics, Moscow Institute of Physics and Technology, Institutskiy lane 9, Dolgoprudnyy, Moskow region 141700, Russia.
P I KuzminA.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow 119071, Russia.
T R GalimzyanovA.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Moscow 119071, Russia.
A V ShnyrovaBiofisika Institute (CSIC, UPV/EHU), University of the Basque Country, barrio Sarriena s/n, 48940 Leioa, Spain; Department of Biochemistry and Molecular Biology, University of the Basque Country, barrio Sarriena s/n, 48940 Leioa, Spain.
P V BashkirovFederal Research and Clinical Center of Physical-Chemical Medicine, Moscow 119435, Russia; Department of Molecular and Biological Physics, Moscow Institute of Physics and Technology, Institutskiy lane 9, Dolgoprudnyy, Moskow region 141700, Russia. Electronic address: pavel.bashkirov@niifhm.ru.
V A FrolovBiofisika Institute (CSIC, UPV/EHU), University of the Basque Country, barrio Sarriena s/n, 48940 Leioa, Spain; Department of Biochemistry and Molecular Biology, University of the Basque Country, barrio Sarriena s/n, 48940 Leioa, Spain; Ikerbasque, Basque Foundation for Science, Maria Diaz de Haro 3, 6 solairua, 48013 Bilbao, Spain. Electronic address: vadim.frolov@ehu.eus.
Frumkin Institute of Physical Chemistry and Electrochemistry · RUResearch Institute of Physical Chemical Medicine · RUBiofisika · ESIkerbasque · ES

Funding

Functional nanoscopy of membrane deformations and fission by dynamin superfamily membersR01GM121725 · NIGMS · UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB · PI FROLOV, VADIM A, NOY, ALEKSANDR · 2017 to 2021
$2.3M
NIGMS NIH HHS R01 GM121725
6 · The paper itself

Abstract

Membrane nanotubes (NTs) and their networks play an important role in intracellular membrane transport and intercellular communications. The transport characteristics of the NT lumen resemble those of conventional solid-state nanopores. However, unlike the rigid pores, the soft membrane wall of the NT can be deformed by forces driving the transport through the NT lumen. This intrinsic coupling between the NT geometry and transport properties remains poorly explored. Using synchronized fluorescence microscopy and conductance measurements, we revealed that the NT shape was changed by both electric and hydrostatic forces driving the ionic and solute fluxes through the NT lumen. Far from the shape instability, the strength of the force effect is determined by the lateral membrane tension and is scaled with membrane elasticity so that the NT can be operated as a linear elastic sensor. Near shape instabilities, the transport forces triggered large-scale shape transformations, both stochastic and periodic. The periodic oscillations were coupled to a vesicle passage along the NT axis, resembling peristaltic transport. The oscillations were parametrically controlled by the electric field, making NT a highly nonlinear nanofluidic circuitry element with biological and technological implications.

Indexed as

NanotubesCell MembraneIon TransportMicroscopy, FluorescenceNonlinear DynamicsSurface TensionElectro-actuationMembrane elasticityMembrane nanotubeNanofluidic transportShape bistability

Identifiers

PMID34118214
PMCPMC8438788
OpenAlexW3168670611

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.