Evidence map›Paper›PMID 34118203›Full record

ArticleDevelopmental cell2021

Oncogene-regulated release of extracellular vesicles.

Seda Kilinc, Rebekka Paisner, Roman Camarda, Suprit Gupta, Olga Momcilovic, Rebecca A Kohnz, Baris Avsaroglu, Noelle D L'Etoile, Rushika M Perera, Daniel K Nomura and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 61 citations in OpenAlex.

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  17. Neuronal Deletion ofBiomolecules · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Seda KilincDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: seda.kilinc@ucsf.edu.
Rebekka PaisnerDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Roman CamardaDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
Suprit GuptaDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.
Olga MomcilovicDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Rebecca A KohnzDepartments of Chemistry and Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Baris AvsarogluDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Noelle D L'EtoileDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.
Rushika M PereraDepartment of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA.
Daniel K NomuraDepartments of Chemistry and Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
Andrei GogaDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: andrei.goga@ucsf.edu.
University of California, San Francisco · USUniversity of California, Berkeley · USUCSF Helen Diller Family Comprehensive Cancer Center · US

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
Molecular and Cellular Mechanisms in CancerT32CA108462 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2004 to 2024
$10.4M
Transcellular epigenetic regulation by ex-small RNA in C. elegantU19CA179512 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BLELLOCH, ROBERT · 2013 to 2017
$7.4M
Tracking tumor evolution through in vivo organelle profilingDP2CA216364 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PERERA, RUSHIKA MIRIAM · 2016 to 2016
$2.4M
Uncovering Mechanisms of Regulation and Dependency on Fatty Acid Oxidation in MYC-Driven TumorsR01CA223817 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2018 to 2022
$1.8M
Dissecting new mechanisms of lysosome quality control in health and diseaseR01CA260249 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PERERA, RUSHIKA MIRIAM · 2021 to 2025
$1.8M
Phinney - Orbitrap Fusion ETDS10OD021801 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PHINNEY, BRETT S · 2016 to 2016
$600k
QE-HF-X Mass SpectrometerS10OD026918 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PHINNEY, BRETT S · 2020 to 2020
$600k
Investigating Fatty Acid Oxidation in Primary and Metastatic MYC-Overexpressing Triple-Negative Breast CancerF99CA212488 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CAMARDA, ROMAN · 2016 to 2017
$72k
NCI NIH HHS DP2 CA216364NCI NIH HHS F99 CA212488NCI NIH HHS R01 CA223817NCI NIH HHS R01 CA260249NCI NIH HHS T32 CA108462NCI NIH HHS U19 CA179512NIDDK NIH HHS P30 DK063720NIH HHS S10 OD021801NIH HHS S10 OD026918
6 · The paper itself

Abstract

Oncogenes can alter metabolism by changing the balance between anabolic and catabolic processes. However, how oncogenes regulate tumor cell biomass remains poorly understood. Using isogenic MCF10A cells transformed with nine different oncogenes, we show that specific oncogenes reduce the biomass of cancer cells by promoting extracellular vesicle (EV) release. While MYC and AURKB elicited the highest number of EVs, each oncogene selectively altered the protein composition of released EVs. Likewise, oncogenes alter secreted miRNAs. MYC-overexpressing cells require ceramide, whereas AURKB requires ESCRT to release high levels of EVs. We identify an inverse relationship between MYC upregulation and activation of the RAS/MEK/ERK signaling pathway for regulating EV release in some tumor cells. Finally, lysosome genes and activity are downregulated in the context of MYC and AURKB, suggesting that cellular contents, instead of being degraded, were released via EVs. Thus, oncogene-mediated biomass regulation via differential EV release is a new metabolic phenotype.

Indexed as

Aurora Kinase BEnergy MetabolismExtracellular VesiclesGene Expression Regulation, NeoplasticGenes, rasHumansLysosomesMAP Kinase Kinase KinasesMAP Kinase Signaling SystemMetabolismOncogenesProto-Oncogene Proteins c-mycSignal TransductionAURKB protein, humanAurora Kinase BMAP Kinase Kinase KinasesMYC protein, humanProto-Oncogene Proteins c-mycAURKBceramideESCRTEVsextracellular vesiclesHRASlysosomemiRNAsMYConcogenes

Identifiers

PMID34118203
PMCPMC8292920
OpenAlexW3171675966

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.