ArticleNeuron2021
A prefrontal network integrates preferences for advance information about uncertain rewards and punishments.
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- A prefrontal cortex-hypothalamus circuit for heart rate control in non-human primates.bioRxiv : the preprint server for biology · 2026Article
- Representations of the intrinsic value of information in mouse orbitofrontal cortex.Nature neuroscience · 2026Article
- Why do we seek information about the future? On the origins of subjective value without instrumental value.bioRxiv : the preprint server for biology · 2026Article
- Ventrolateral prefrontal cortex in macaques guides decisions in different learning conditions.Nature communications · 2026Article
- Alterations of static and dynamic functional connectivity of the nucleus accumbens subregions may be associated with chronic process of migraine: a resting-state fMRI study.The journal of headache and pain · 2026Article
- Prefrontal inhibitory mechanisms associated with Putamen activity during valence learning revealed by multimodal fMRI-fMRS.Communications biology · 2025Article
- Article
- Neuronal Decoding of Decisions in Multidimensional Feature Space Using a Gated Recurrent Variational Autoencoder.bioRxiv : the preprint server for biology · 2025Article
- Chemogenetic inhibition of amygdala to ventrolateral prefrontal cortex communication selectively impacts contingent learning.bioRxiv : the preprint server for biology · 2025Article
- The effect of doll blind box uncertainty on consumers' irrational consumption behavior: the role of instant gratification, Gambler's fallacy, and perceived scarcity.BMC psychology · 2025Article
- Acetylcholine modulates prefrontal outcome coding during threat learning under uncertainty.eLife · 2025Article
- Distinct neural computations scale the violation of expected reward and emotion in social transgressions.Communications biology · 2025Article
- Flight training and the anterior cingulate cortex.Scientific reports · 2024Article
- Ventral frontostriatal circuitry mediates the computation of reinforcement from symbolic gains and losses.Neuron · 2024Article
- Three diverse motives for information sharing.Communications psychology · 2024Article
- Decision-making shapes dynamic inter-areal communication within macaque ventral frontal cortex.Current biology : CB · 2024Article
- Dissociable Representations of Decision Variables within Subdivisions of the Macaque Orbital and Ventrolateral Frontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Decision-making shapes dynamic inter-areal communication within macaque ventral frontal cortex.bioRxiv : the preprint server for biology · 2024Article
- Article
- A special role for anterior cingulate cortex, but not orbitofrontal cortex or basolateral amygdala, in choices involving information.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
Humans and animals can be strongly motivated to seek information to resolve uncertainty about rewards and punishments. In particular, despite its clinical and societal relevance, very little is known about information seeking about punishments. We show that attitudes toward information about punishments and rewards are distinct and separable at both behavioral and neuronal levels. We demonstrate the existence of prefrontal neuronal populations that anticipate opportunities to gain information in a relatively valence-specific manner, separately anticipating information about either punishments or rewards. These neurons are located in anatomically interconnected subregions of anterior cingulate cortex (ACC) and ventrolateral prefrontal cortex (vlPFC) in area 12o/47. Unlike ACC, vlPFC also contains a population of neurons that integrate attitudes toward both reward and punishment information, to encode the overall preference for information in a bivalent manner. This cortical network is well suited to mediate information seeking by integrating the desire to resolve uncertainty about multiple, distinct motivational outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.