ArticleJournal of clinical hypertension (Greenwich, Conn.)2021
The association of triglyceride and glucose index, and triglyceride to high-density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: A large cross-sectional population study.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- The triglyceride-glucose index is associated with a higher risk of hypertension: evidence from a cross-sectional study of Chinese adults and meta-analysis of epidemiology studies.Frontiers in endocrinology · 2025Pooled it
- Relationship between the triglyceride-glucose index and risk of cardiovascular diseases and mortality in the general population: a systematic review and meta-analysis.Cardiovascular diabetology · 2022Pooled it
- Triglyceride-glucose index normalized by waist circumference and life's simple 7 to identify high-risk hypertensive patients in primary care.BMC primary care · 2026Article
- Triglyceride-glucose index as a biochemical predictor of hypertension in patients with type 2 diabetes and prediabetes: Evidence from the NHANES database.Journal of medical biochemistry · 2026Article
- A Link Between the Triglyceride-Glucose Index and the Risk of Hypertension Among Employees in the Titanium Dioxide Industry.Vascular health and risk management · 2026Article
- Association between TG/HDL-C ratio or triglyceride-glucose index and mean arterial pressure in patients with myocardial infarction.Scientific reports · 2025Article
- Association between triglyceride-glucose index and hypertension in adults with cancer from NHANES 2005-2018: a cross-sectional study.BMC cancer · 2025Article
- Association between triglyceride-glucose index multiplied by waist circumference and H-type hypertension among Chinese adults.Frontiers in cardiovascular medicine · 2025Article
- Association of Triglyceride-Glucose Index, Triglyceride to High-Density Lipoprotein Cholesterol Ratio, and Related Parameters With Prehypertension and Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Elevated triglyceride-glucose index increases risk in patients with retinal vein occlusion.Frontiers in medicine · 2025Article
- Utility of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in individuals with retinal vein occlusion.Frontiers in cardiovascular medicine · 2025Article
- Nonlinear relationship between TyG index and the risk of non-alcoholic fatty liver disease in Chinese population: a cross-sectional study.American journal of translational research · 2025Article
- Mediating role of triglyceride glucose-related index in the associations of composite dietary antioxidant index with cardiovascular disease and mortality in older adults with hypertension: a national cohort study.Frontiers in nutrition · 2025Article
- Childhood triglyceride-glucose index and pre-hypertension in adulthood: a prospective cohort study.Frontiers in endocrinology · 2025Article
- Elevated triglyceride-glucose index is a risk factor for progression to prehypertension in normoglycemic Japanese: a 5-year retrospective cohort study.Clinical hypertension · 2024Article
- The synergistic effect of triglyceride-glucose index and HbA1c on blood pressure control in patients with hypertension: a retrospective cohort study.Scientific reports · 2024Article
- Association of triglyceride‑glucose index in branch retinal vein occlusion.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Association of TyG index and central obesity with hypertension in middle-aged and elderly Chinese adults: a prospective cohort study.Scientific reports · 2024Article
- The effect of insulin resistance in the association between obesity and hypertension incidence among Chinese middle-aged and older adults: data from China health and retirement longitudinal study (CHARLS).Frontiers in public health · 2024Article
- Adipocentric origin of the common cardiometabolic complications of obesity in the young up to the very old: pathophysiology and new therapeutic opportunities.Frontiers in medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin resistance (IR) plays an important role in the development of hypertension. Triglyceride and glucose index (TyG index), and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-c) as effective IR surrogate indexes have been verified in numerous studies. Therefore, the authors conducted a large cross-sectional study to explore the association of TyG index and TG/HDL-c with prehypertension and hypertension in the same normoglycemic subjects from Tianjin, China. A total of 32 124 adults were eligible for this study. According to the level of blood pressure, the enrolled individuals were divided into three groups, which were normotension, prehypertension, and hypertension. In multiple logistic regression analysis, there was associated with prehypertension and hypertension when comparing the highest TyG index to the lowest TyG index and corresponding ORs were 1.795 (1.638, 1.968) and 2.439 (2.205, 2.698), respectively. For TG/HDL-c, the corresponding ORs were 1.514 (1.382, 1.658) and 1.934 (1.751, 2.137), respectively. Furthermore, when comparing the fourth quartile to the first quartile of TyG index and TG/HDL-c, respectively, both corresponding ORs of hypertension were higher than prehypertension. Elevated TyG index and TG/HDL-c levels were associated with prehypertension and hypertension in normoglycemic individuals. Moreover, the TyG index was more significant than TG/HDL-c in distinguishing hypertension. They have the potential to become cost-effective monitors in the hierarchical management of prehypertension and hypertension.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.