Evidence map›Paper›PMID 34117997›Full record

ReviewStem cell reviews and reports2021

Mesenchymal Stem Cells: A Novel Therapeutic Approach to Enhance Protective Immunomodulation and Erythropoietic Recovery in Malaria.

Meenu Kalkal, Mrinalini Tiwari, Reva S Thakur, Vikky Awasthi, Veena Pande, Debprasad Chattopadhyay, Jyoti Das

Open access · bronzeAbstract readReview
In one paragraph

Review in Stem cell reviews and reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. The LEF1-LAG3 axis regulates CD4Parasites & vectors · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. 3D Culture of MSCs for Clinical Application.Bioengineering (Basel, Switzerland) · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Meenu Kalkal *Parasite-Host Biology, National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, 110077, India.
Mrinalini Tiwari *Department of Genetics and Epigenetics, Institute of Nuclear Medicine & Allied Science, Timarpur, New Delhi, 110054, India.
Reva S ThakurParasite-Host Biology, National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, 110077, India.
Vikky AwasthiParasite-Host Biology, National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, 110077, India.
Veena PandeDepartment of Biotechnology, Kumaun University, Nanital, 263001, India.
Debprasad ChattopadhyayICMR Virus Unit, ID & BG Hospital, Kolkata, 700010, India.
Jyoti DasParasite-Host Biology, National Institute of Malaria Research, Sector-8, Dwarka, New Delhi, 110077, India. jyoti@mrcindia.org.ORCID http://orcid.org/0000-0001-8134-593X
National Institute of Malaria Research · INInstitute of Nuclear Medicine & Allied Sciences · INKumaun University · INVirus Unit · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) are self-renewing, multi-potent heterogeneous stem cells that display strong tissue protective and restorative properties by differentiating into cells of the mesodermal lineages. In addition to multi-lineage differentiation capacity, MSCs play important roles in regulating immune responses, inflammation, and tissue regeneration. MSCs play a role in the outcome of the pathogenesis of several infectious diseases. A unique subset of MSCs accumulates in secondary lymphoid organs during malaria disease progression. These MSCs counteract the capacity of malaria parasites to subvert activating co-stimulatory molecules and to regulate expression of negative co-stimulatory molecules on T lymphocytes. Consequently, MSCs have the capacity to restore the functions of CD34

Indexed as

MalariaMesenchymal Stem CellsCD8-Positive T-LymphocytesErythropoiesisHumansImmunityImmunomodulationErythropoiesisHaematopoiesisHaematopoietic stem cells (HSCs)ImmunomodulationMalariaMesenchymal stem cells (MSCs)Plasmodium

Identifiers

PMID34117997
PMCPMC8196918
OpenAlexW3168940410

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.