Evidence map›Paper›PMID 34117990›Full record

ArticleInternational journal of hematology2021

Incidence and risk factors of late-onset hemorrhagic cystitis after single umbilical cord blood transplantation with myeloablative conditioning regimen.

Huimin Jiang, Liangquan Geng, Xiang Wan, Kaidi Song, Juan Tong, Xiaoyu Zhu, Baolin Tang, Wen Yao, Xuhan Zhang, Guangyu Sun and 3 more

Abstract read
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In one paragraph

Article in International journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Huimin JiangDepartment of Hematology of Anhui Provincial Hospital, Anhui Medical University, Hefei, China.
Liangquan GengDepartment of Hematology, the First Affiliated Hospital of University of Science and Technology of China, No.17, Lujiang Road, Hefei, Anhui, China.
Xiang WanDepartment of Hematology, the First Affiliated Hospital of University of Science and Technology of China, No.17, Lujiang Road, Hefei, Anhui, China.
Kaidi SongDepartment of Hematology, the First Affiliated Hospital of University of Science and Technology of China, No.17, Lujiang Road, Hefei, Anhui, China.
Juan TongDepartment of Hematology, the First Affiliated Hospital of University of Science and Technology of China, No.17, Lujiang Road, Hefei, Anhui, China.
Xiaoyu ZhuDepartment of Hematology, the First Affiliated Hospital of University of Science and Technology of China, No.17, Lujiang Road, Hefei, Anhui, China.
Baolin TangDepartment of Hematology, the First Affiliated Hospital of University of Science and Technology of China, No.17, Lujiang Road, Hefei, Anhui, China.
Wen YaoDepartment of Hematology, the First Affiliated Hospital of University of Science and Technology of China, No.17, Lujiang Road, Hefei, Anhui, China.
Xuhan ZhangDepartment of Hematology, the First Affiliated Hospital of University of Science and Technology of China, No.17, Lujiang Road, Hefei, Anhui, China.
Guangyu SunDepartment of Hematology, the First Affiliated Hospital of University of Science and Technology of China, No.17, Lujiang Road, Hefei, Anhui, China.
Lei ZhangDepartment of Hematology, the First Affiliated Hospital of University of Science and Technology of China, No.17, Lujiang Road, Hefei, Anhui, China.
Zimin SunDepartment of Hematology, the First Affiliated Hospital of University of Science and Technology of China, No.17, Lujiang Road, Hefei, Anhui, China.
Huilan LiuDepartment of Hematology of Anhui Provincial Hospital, Anhui Medical University, Hefei, China. huilanl@ustc.edu.cn.ORCID http://orcid.org/0000-0002-8534-6646
University of Science and Technology of China · CNAnhui Medical University · CN

Funding

program of Key Research and Development Plan in Anhui 1704a0802149the Fundamental Research Funds for the Central Universities WK9110000001
6 · The paper itself

Abstract

objectiveTo explore the incidence and risk factors of late-onset hemorrhagic cystitis (LOHC) in patients undergoing single umbilical cord blood transplantation for hematological malignancies.

methodsClinical data from 234 patients who consecutively underwent single UCBT using a myeloablative conditioning regimen without antithymocyte globulin in our center were retrospectively analyzed.

resultsIn total, 64 (27.4%) patients developed LOHC with a median onset time of 40.5 (range 8-154) days, and 15 (6.4%) patients gradually developed grade III-IV LOHC. The incidence of LOHC was marginally higher in adults (31.0%) than in children (23.7%) (p = 0.248). HLA matching ≤ 6/8 (HR = 2.624, 95% CI 1.112-6.191, p = 0.028) was an independent risk factor for LOHC. The overall survival of LOHC patients (59.8%, 95% CI 61.7-85.5%) was significantly lower than that of patients without LOHC (86.8%, 95% CI 79.6-91.6%) at 130 days post transplantation (p = 0.036).

conclusionPatients with less well-matched grafts have a higher incidence of LOHC. Inherent deficiencies in immunity in the context of HLA disparity and more intense pharmacologic immunosuppression after severe acute graft-versus-host disease may contribute to viral activation. Prevention and treatment of LOHC have the potential to prolong long-term survival.

Indexed as

AdolescentAdultAgedChildCord Blood Stem Cell TransplantationCystitisFemaleGraft vs Host DiseaseHemorrhageHumansIncidenceMaleMiddle AgedPre-Exposure ProphylaxisPrognosisRisk FactorsHematological malignanciesLate-onset hemorrhagic cystitisUmbilical cord blood transplantationVirus infection

Identifiers

PMID34117990
OpenAlexW3167167742

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.