ArticleBehavior genetics2021
Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use.
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Article in Behavior genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Patterns, Predictors, and Correlates of Problematic Alcohol Use and Remission From Adolescence to Early Midlife.Alcohol, clinical & experimental research · 2026Article
- Gene-Environment Interplay Beyond Interactions: Psychosocial Environments Mediate Genetic Effects Underlying Externalizing-Behavior Trajectories.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- Do polygenic indices capture "direct" effects on child externalizing behavior problems? Within-family analyses in two longitudinal birth cohorts.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood.Psychological medicine · 2024Article
- Limited psychological and social effects of lifetime cannabis use frequency: Evidence from a 30-year community study of 4,078 twins.Journal of psychopathology and clinical science · 2024Article
- The Collaborative Study on the Genetics of Alcoholism: Overview.Genes, brain, and behavior · 2023Review
- Polygenic Effects on Individual Rule Breaking, Peer Rule Breaking, and Alcohol Sips Across Early Adolescence in the ABCD Study.Research on child and adolescent psychopathology · 2023Article
- 5. Collaborative Study on the Genetics of Alcoholism: Functional genomics.Genes, brain, and behavior · 2023Review
- The collaborative study on the genetics of alcoholism: Sample and clinical data.Genes, brain, and behavior · 2023Review
- A person-centered data analytic approach to dopaminergic polygenic moderation of child maltreatment exposure.Developmental psychobiology · 2023Article
- Do polygenic indices capture "direct" effects on child externalizing behavior? Within-family analyses in two longitudinal birth cohorts.medRxiv : the preprint server for health sciences · 2023Article
- Unraveling the Bidirectional Associations between Parental Knowledge and Children's Externalizing Behavior.Journal of youth and adolescence · 2023Article
- Hazardous drinking and alcohol use disorders.Nature reviews. Disease primers · 2022Review
- Associations between parenting characteristics and adolescent substance use: A genetically informed, longitudinal adoption study.Development and psychopathology · 2022Article
- A broad internalizing dimension accounts for the genetic associations between personality and individual internalizing disorders.Journal of psychopathology and clinical science · 2022Article
- An Introduction to the Special Issue: Developmental Behavior Genetics and Externalizing Psychopathology.Behavior genetics · 2021Article
Corrections and comments
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Authors and funding
21 authors at 9 institutions in 1 country.
Sally I-Chun KuoDepartment of Psychology, Virginia Commonwealth University, Box 842018, 806 W Franklin St, Richmond, VA, 23284, USA. ickuo@vcu.edu.ORCID http://orcid.org/0000-0002-6192-1001
Jessica E SalvatoreDepartment of Psychology, Virginia Commonwealth University, Box 842018, 806 W Franklin St, Richmond, VA, 23284, USA.
Peter B BarrDepartment of Psychology, Virginia Commonwealth University, Box 842018, 806 W Franklin St, Richmond, VA, 23284, USA.
Fazil AlievDepartment of Psychology, Virginia Commonwealth University, Box 842018, 806 W Franklin St, Richmond, VA, 23284, USA.
Andrey AnokhinDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
Kathleen K BucholzDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
Grace ChanDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA.
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University, Indianapolis, IN, USA.
Victor HesselbrockDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA.
Chella KamarajanDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
John R KramerDepartment of Psychiatry, University of Iowa, Iowa City, IA, USA.
Dongbing LaiDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
Travis T MallardDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
John I NurnbergerDepartment of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
Gayathri PandeyDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
Martin H PlaweckiDepartment of Psychiatry, Indiana University, Indianapolis, IN, USA.
Sandra Sanchez-RoigeDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Irwin WaldmanDepartment of Psychology, Emory University, Atlanta, GA, USA.
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Externalizing Consortium
Danielle M DickDepartment of Psychology, Virginia Commonwealth University, Box 842018, 806 W Franklin St, Richmond, VA, 23284, USA.
Virginia Commonwealth University · USIndiana University – Purdue University Indianapolis · USState University of New York · USUniversity of California San Diego · USUniversity of Connecticut · USWashington University in St. Louis · USEmory University · USThe University of Texas at Austin · USUniversity of Iowa · US
Funding
Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MProject 5 - Genetic architecture of alcohol use disorder using cross-trait genetic correlations and public next-generation sequencing studiesP50AA022537 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI JILL C BETTINGER · 2014 to 2026
$19.6MUsing the Genetic Architecture of Substance Use Disorders to Advance Gene Identification and Understanding of Pathways of RiskR01DA050721 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DANIELLE M DICK · 2020 to 2026
$3.9MTwin, molecular, and developmental approaches to understanding alcohol misuseK02AA018755 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DICK, DANIELLE M · 2010 to 2019
$1.3MGenetics, Romantic Relationships, and Alcohol Misuse in Emerging AdulthoodK01AA024152 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI SALVATORE, JESSICA E · 2016 to 2020
$741kNIAAA NIH HHS K01 AA024152NIAAA NIH HHS K02 AA018755NIAAA NIH HHS P50 AA022537NIAAA NIH HHS U10 AA008401NIA NIH HHS U24 AG021886NIDA NIH HHS R01 DA050721
Abstract
Genetic predispositions and environmental influences both play an important role in adolescent externalizing behavior; however, they are not always independent. To elucidate gene-environment interplay, we examined the interrelationships between externalizing polygenic risk scores, parental knowledge, and peer substance use in impacting adolescent externalizing behavior across two time-points in a high-risk longitudinal sample of 1,200 adolescents (764 European and 436 African ancestry; M
Indexed as
Adolescent BehaviorSubstance-Related DisordersAdolescentChildHumansLongitudinal StudiesMultifactorial InheritanceParentingParentsPeer GroupRisk FactorsAdolescent externalizingGene–environment interplayParentingPeersPolygenic score
Identifiers
PMID
34117972PMC
PMC8403154OpenAlex
W3168615519What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.